All Phenotypes Pdpn<tm1Acgg> MGI Mouse

lethality throughout fetal growth and development, incomplete penetrance ( J:132132 )

• 40% of homozygotes die between E10 and E16; highest rate of mortality is during later fetal period (E10-13)

neonatal lethality, incomplete penetrance ( J:132132 )

• 50% of neonatal mice die within the first weeks of birth

embryonic lethality during organogenesis, incomplete penetrance ( J:132132 )

• highest rate of death is observed between E10 and E13

abnormal coronary artery morphology ( J:132132 )

• some hearts at E14.5 show diminished presence of smooth muscle cells in coronary artery media, and in a few hearts, additional (pinpoint) coronary orifices are observed

• one heart at E14.5 has a double left coronary orifice and absent right coronary orifice

• all hearts examined at E15.5 have deficiency of smooth muscle cells in coronary artery media

abnormal myocardium layer morphology ( J:132132 )

• myocardium of atrial and ventricular wall display perforations resulting in continuity between the subendocardial and subepicardial layers

• abnormal myocardial architecture is present in animals at E14.5 and some mutants display partial epicardial dissociation

• at E14.5 and E15.5, mutants with normal epicardial morphology still show decreased myocardial volume

abnormal myocardial trabeculae morphology ( J:132132 )

• hypoplastic at E11.5

abnormal myocardium compact layer morphology ( J:132132 )

• compact atrial and ventricular myocardium are hypoplastic at E12.5

thin myocardium ( J:132132 )

• at younger embryonic stages, hypoplastic myocardium phenotype is seen with thin atrial and ventricular myocardium

abnormal heart development ( J:132132 )

decreased atrioventricular cushion size ( J:132132 )

• atrioventricular endocardial cushions are widely separated and have not begun to fuse at E11.5, in contrast to wild-type

abnormal heart and great artery attachment ( J:132132 )

• aorta is more dextroposed compared to wild-type and is still positioned above right ventricle at E12.5

• aorta and pulmonary trunk have side-by-side position

abnormal interventricular septum morphology ( J:132132 )

• developing ventricular septum is fenestrated compared to wild-type at E12.5

detached epicardium ( J:132132 )

• embryos show incomplete covering and dissociation of epicardium from the myocardium at E11.5

• with severe hypoplasia of atrial and ventricular compact myocardium and trabeculae, epicardial dissociation and incomplete covering are distinct at E12.5

• at E13.5, some embryos show partial epicardial dissociation without severe myocardial hypoplasia

• at E15.5, some embryos display epicardial dissociation with mild hypoplasia of the compact myocardium