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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(S100a4-cre)1Gle
transgene insertion 1, Gustavo Leone
MGI:3775823
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ets2tm1Rgo/Ets2tm5.1Rgo
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(S100a4-cre)1Gle/0 		involves: 129S2/SvPas * FVB/N MGI:4366764
cn2
 		Ets2tm1Rgo/Ets2tm5.1Rgo
Tg(MMTV-PyVT)634Mul/0
Tg(S100a4-cre)1Gle/0 		involves: 129S2/SvPas * FVB/N MGI:4366767
cn3
 		Ets2tm1Rgo/Ets2tm5.1Rgo
Tg(S100a4-cre)1Gle/0 		involves: 129S2/SvPas * FVB/N MGI:4366768
cn4
 		Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(S100a4-cre)1Gle/0 		involves: FVB/N MGI:4366765
cn5
 		Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(MMTVneu)202Mul/0
Tg(S100a4-cre)1Gle/0 		involves: FVB/N MGI:4366766


Genotype
MGI:4366764
cn1
Allelic
Composition		 Ets2tm1Rgo/Ets2tm5.1Rgo
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(S100a4-cre)1Gle/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm1Rgo mutation (1 available); any Ets2 mutation (39 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (39 available)
Ptentm1.1Mwst mutation (0 available); any Pten mutation (88 available)
Tg(S100a4-cre)1Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased mammary gland tumor incidence ( J:153747 )
• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(S100a4-cre)1Gle mice
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes
abnormal tumor morphology ( J:153747 )
• mammary tumors induced by NT2.5 exhibit decreased numbers of macrophages and recruitment of new vasculature compared to in similarly treated Ptentm1.1Mwst homozygotes

integument
decreased mammary gland tumor incidence ( J:153747 )
• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(S100a4-cre)1Gle mice
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes

endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:153747 )
• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(S100a4-cre)1Gle mice
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes




Genotype
MGI:4366767
cn2
Allelic
Composition		 Ets2tm1Rgo/Ets2tm5.1Rgo
Tg(MMTV-PyVT)634Mul/0
Tg(S100a4-cre)1Gle/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm1Rgo mutation (1 available); any Ets2 mutation (39 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (39 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
Tg(S100a4-cre)1Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased mammary gland tumor incidence ( J:153747 )
• fewer mammary tumors form than in Ets2tm1Rgo/Ets2tm5.1Rgo Tg(MMTV-PyVT)634Mul mice and progression to adenoma and early carcinoma is slowed

integument
decreased mammary gland tumor incidence ( J:153747 )
• fewer mammary tumors form than in Ets2tm1Rgo/Ets2tm5.1Rgo Tg(MMTV-PyVT)634Mul mice and progression to adenoma and early carcinoma is slowed

endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:153747 )
• fewer mammary tumors form than in Ets2tm1Rgo/Ets2tm5.1Rgo Tg(MMTV-PyVT)634Mul mice and progression to adenoma and early carcinoma is slowed




Genotype
MGI:4366768
cn3
Allelic
Composition		 Ets2tm1Rgo/Ets2tm5.1Rgo
Tg(S100a4-cre)1Gle/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm1Rgo mutation (1 available); any Ets2 mutation (39 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (39 available)
Tg(S100a4-cre)1Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:153747 )
N
• mice exhibit normal mammary gland development




Genotype
MGI:4366765
cn4
Allelic
Composition		 Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(S100a4-cre)1Gle/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Mwst mutation (0 available); any Pten mutation (88 available)
Tg(S100a4-cre)1Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes

integument
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes




Genotype
MGI:4366766
cn5
Allelic
Composition		 Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(MMTVneu)202Mul/0
Tg(S100a4-cre)1Gle/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1.1Mwst mutation (0 available); any Pten mutation (88 available)
Tg(MMTVneu)202Mul mutation (2 available)
Tg(S100a4-cre)1Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:153747 )
• mesenchymal cells transplanted into wild-type mice induce more mammary tumors that similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(MMTVneu)202Mul cells
• mammary tumors progress to adenoma, carcinoma in situ, and invasive carcinoma

integument
increased mammary gland tumor incidence ( J:153747 )
• mesenchymal cells transplanted into wild-type mice induce more mammary tumors that similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(MMTVneu)202Mul cells
• mammary tumors progress to adenoma, carcinoma in situ, and invasive carcinoma

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:153747 )
• mesenchymal cells transplanted into wild-type mice induce more mammary tumors that similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(MMTVneu)202Mul cells
• mammary tumors progress to adenoma, carcinoma in situ, and invasive carcinoma




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory