All Phenotypes Nras<tm1Tyj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nras^tm1Tyj
targeted mutation 1, Tyler Jacks
MGI:3775824

Summary

14 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nras^tm1Tyj/Nras⁺ Meox2^tm1(cre)Sor/Meox2⁺	B6.Cg-Nras^tm1Tyj Meox2^tm1(cre)Sor	MGI:7544840
cn2	Nras^tm1Tyj/Nras⁺ Tg(Tek-cre)1Ywa/0	B6.Cg-Nras^tm1Tyj Tg(Tek-cre)1Ywa	MGI:7544842
cn3	Nras^tm1Tyj/Nras⁺ Tg(Tnnt2-cre)5Blh/0	B6.Cg-Nras^tm1Tyj Tg(Tnnt2-cre)5Blh	MGI:7544844
cn4	Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh Nras^tm1Tyj/Nras^tm1Tyj Tg(Tyr-cre/ERT2)13Bos/0	B6J.Cg-Tg(Tyr-cre/ERT2)13Bos Nras^tm1Tyj Cdkn2a^tm2.1Nesh	MGI:5752233
cn5	Nras^tm1Tyj/Nras⁺ Meox2^tm1(cre)Sor/Meox2⁺	involves: 129S4/SvJaeSor * C57BL/6	MGI:5284833
cn6	Zdhhc9^tm1Lex/Y Nras^tm1Tyj/Nras^tm1Tyj Tg(Mx1-cre)1Cgn/0	involves: 129S5/SvEvBrd * C57BL/6 * CBA	MGI:6771589
cn7	Nras^tm1Tyj/Nras^tm1Tyj Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA	MGI:5563459
cn8	Nras^tm1Tyj/Nras^tm2.1Tyj Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA	MGI:5563458
cn9	Nras^tm1Tyj/Nras⁺ Tg(Tyr-cre/ERT2)1Lru/0	involves: C57BL/6 * DBA/2	MGI:5755095
cn10	Nras^tm1Tyj/Nras⁺ Tg(Vil1-cre)20Syr/0	involves: C57BL/6 * DBA/2	MGI:3776027
cn11	Nras^tm1Tyj/Nras^tm1Tyj Tg(Tyr-cre/ERT2)1Lru/0	involves: C57BL/6 * DBA/2	MGI:5755094
cn12	Nras^tm1Tyj/Nras^tm1Tyj Tg(Tyr-cre)1Lru/0	involves: C57BL/6 * DBA/2	MGI:5755097
cn13	Nras^tm1Tyj/Nras⁺ Tg(Tyr-cre)1Lru/0	involves: C57BL/6 * DBA/2	MGI:5755101
cn14	Nras^tm1Tyj/Nras⁺ Tg(Fabp1-cre)1Jig/0	involves: C57BL/6 * FVB/N	MGI:3776024

Allelic Composition	Nras^tm1Tyj/Nras⁺ Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	B6.Cg-Nras^tm1Tyj Meox2^tm1(cre)Sor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2^tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Nras^tm1Tyj mutation (1 available); any Nras mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:305401 )

• embryos are recovered at normal numbers at E12.5-E14.5; however, all embryos die between E15.5 and E17.5

growth/size/body

decreased fetal size ( J:305401 )

• at E15.5, embryos are smaller than control embryos

• however, embryos are grossly normal at E13.5

integument

pallor ( J:305401 )

• embryos exhibit pale bodies at E15.5

homeostasis/metabolism

hydrops fetalis ( J:305401 )

• at E15.5, embryos display whole-body edema

cardiovascular system

abnormal heart morphology ( J:305401 )

• starting at E13.5, hearts show morphological defects that resemble congenital cardiac defects seen in Noonan syndrome patients

myocardial hypertrabeculation ( J:305401 )

• at E13.5, hearts exhibit myocardial hypertrabeculation

thin ventricle myocardium compact layer ( J:305401 )

• at E13.5, the compact layer thickness in the right and left heart ventricle is reduced by 62.5 and 45.5%, respectively

thin myocardium ( J:305401 )

• at E13.5, 4 of 6 hearts exhibit a thin myocardium

abnormal heart development ( J:305401 )

• at E13.5, hearts exhibit downregulated non-canonical Wnt and BMP pathways and hyperactivated MEK/ERK signaling, indicating dysregulation of critical pathways involved in heart development

• however, no alterations in cell proliferation or apoptosis are observed in the heart at E13.5

abnormal pulmonary valve development ( J:305401 )

• pulmonary valves are not remodeled properly

double outlet right ventricle ( J:305401 )

• at E13.5, 4 of 6 hearts exhibit a DORV phenotype, where both the aorta and pulmonary trunk exit the right ventricle

ventricular septal defect ( J:305401 )

• at E13.5, all (6 of 6) hearts show ventricular septal defects (VSDs); the interventricular septum fails to fuse with the endocardial cushion, unlike in control hearts

pulmonary valve stenosis ( J:305401 )

• at E13.5, 4 of 6 hearts exhibit pulmonary valve stenosis

thin ventricular wall ( J:305401 )

liver/biliary system

small liver ( J:305401 )

• fetal livers are smaller at E15.5

hepatic necrosis ( J:305401 )

• at E15.5, hepatic necrosis is observed, esp. in the regions distal from blood flow

hematopoietic system

abnormal definitive hematopoiesis ( J:305401 )

• fetal liver hematopoiesis is mildly perturbed at E13.5

increased erythroid progenitor cell number ( J:305401 )

• at E13.5, fetal livers show a moderate expansion of Ter119- CD71^mid/hi cells that are enriched with colony forming unit-erythroid (CFU-E) progenitors and early erythroblasts

• however, the % of terminally differentiating Ter119+ erythroid cells is similar to that of controls

increased hematopoietic stem cell number ( J:305401 )

• at E13.5, embryos show a moderate expansion of hematopoietic stem and progenitor cells in the fetal liver

abnormal fetal liver hematopoietic progenitor cell morphology ( J:305401 )

• at E13.5, embryos show a moderate expansion of hematopoietic stem and progenitor cells in the fetal liver; both HSCs (defined as Lin- Mac1+ CD41- CD48- CD150+ Sca1+ cKit+) and LSK cells (hematopoietic stem and progenitor cells, defined as Lin- Sca1+ cKit+) are expanded

muscle

myocardial hypertrabeculation ( J:305401 )

• at E13.5, hearts exhibit myocardial hypertrabeculation

thin ventricle myocardium compact layer ( J:305401 )

• at E13.5, the compact layer thickness in the right and left heart ventricle is reduced by 62.5 and 45.5%, respectively

thin myocardium ( J:305401 )

• at E13.5, 4 of 6 hearts exhibit a thin myocardium

Allelic Composition	Nras^tm1Tyj/Nras⁺ Tg(Tek-cre)1Ywa/0
Genetic Background	B6.Cg-Nras^tm1Tyj Tg(Tek-cre)1Ywa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (44 available)
Tg(Tek-cre)1Ywa mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:305401 )

• live embryos are recovered at normal numbers at E14.5; however, all embryos die by E17.5

cardiovascular system

myocardial hypertrabeculation ( J:305401 )

• at E13.5, three of 5 hearts exhibit myocardial hypertrabeculation

thin ventricle myocardium compact layer ( J:305401 )

• at E13.5, three of 5 hearts exhibit a thin compact layer with a deeply invaginated trabecular layer

double outlet right ventricle ( J:305401 )

• at E13.5, two of 5 hearts exhibit DORV

ventricular septal defect ( J:305401 )

• at E13.5, two of 5 hearts show ventricular septal defects (VSDs)

pulmonary valve stenosis ( J:305401 )

• at E13.5, two of 5 hearts exhibit pulmonary valve stenosis

muscle

myocardial hypertrabeculation ( J:305401 )

• at E13.5, three of 5 hearts exhibit myocardial hypertrabeculation

thin ventricle myocardium compact layer ( J:305401 )

• at E13.5, three of 5 hearts exhibit a thin compact layer with a deeply invaginated trabecular layer

Allelic Composition	Nras^tm1Tyj/Nras⁺ Tg(Tnnt2-cre)5Blh/0
Genetic Background	B6.Cg-Nras^tm1Tyj Tg(Tnnt2-cre)5Blh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (44 available)
Tg(Tnnt2-cre)5Blh mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:305401 )

N	• mice exhibit normal viability during embryonic development

cardiovascular system

cardiovascular system phenotype ( J:305401 )

N	• mice do NOT exhibit any gross cardiac malformations during embryonic development

Allelic Composition	Cdkn2a^tm2.1Nesh/Cdkn2a^tm2.1Nesh Nras^tm1Tyj/Nras^tm1Tyj Tg(Tyr-cre/ERT2)13Bos/0
Genetic Background	B6J.Cg-Tg(Tyr-cre/ERT2)13Bos Nras^tm1Tyj Cdkn2a^tm2.1Nesh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm2.1Nesh mutation (4 available); any Cdkn2a mutation (67 available)
Nras^tm1Tyj mutation (1 available); any Nras mutation (44 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal melanocyte proliferation ( J:220627 )

• melanocytes treated with 4-hydroxytamoxifen (4-OHT) to induce cre activity exhibit decreased proliferation in culture and cease to proliferate after 2-3 passages

integument

increased cutaneous melanoma incidence ( J:220627 )

• melanoma is very rare in mice treated with 4-OHT neonatally, with 1 in 29 mice developing tumors when observed for 80 weeks

pigmentation

abnormal melanocyte proliferation ( J:220627 )

• melanocytes treated with 4-hydroxytamoxifen (4-OHT) to induce cre activity exhibit decreased proliferation in culture and cease to proliferate after 2-3 passages

hyperpigmentation ( J:220627 )

• mice treated with 4-OHT neonatally exhibit the presence of nevi and hyperpigmented regions on the paws and tails

neoplasm

increased cutaneous melanoma incidence ( J:220627 )

• melanoma is very rare in mice treated with 4-OHT neonatally, with 1 in 29 mice developing tumors when observed for 80 weeks

Allelic Composition	Nras^tm1Tyj/Nras⁺ Meox2^tm1(cre)Sor/Meox2⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:174880 )

• no mice born alive

Allelic Composition	Zdhhc9^tm1Lex/Y Nras^tm1Tyj/Nras^tm1Tyj Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (44 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
Zdhhc9^tm1Lex mutation (2 available); any Zdhhc9 mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased leukemia incidence ( J:231488 )

• when bone marrow (BM) cells from polyinosinic-polycytidylic acid (pIpC)-treated mutant mice (CD45.2) are transplanted into lethally irradiated (CD45.1) recipient mice, less than 70% of recipients of mutant donor BM cells develop T cell acute lymphoblastic leukemia (T-ALL) with a slower progression and a median survival of 390 days post-transplantation versus 202 days for recipients of wild-type donor BM cells

• after oncogenic Nras activation by pIpC injection, mice develop a chronic myelomonocytic leukemia (CMML)-like disease with a significantly slower progression and a median survival of 173 days post-injection versus 152 days for control mice

Allelic Composition	Nras^tm1Tyj/Nras^tm1Tyj Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (44 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:204263 )

• some pIpC-treated mice die prematurely from T lineage acute lymphoblastic leukemia

hematopoietic system

enlarged spleen ( J:174880 , J:204263 )

• marked splenomegaly 2 days after pIpC induction (J:174880)

• in pIpC-treated mice (J:204263)

abnormal definitive hematopoiesis ( J:204263 )

• cells from pIpC-treated mice exhibit cytokine-independent CFU-GM growth and pronounced GM-CSF hypersensitivity compared with control cells

abnormal myelopoiesis ( J:174880 )

• display a myeloproliferative phenotype 2 days after pIpC induction

myeloid hyperplasia ( J:204263 )

• all pIpC-treated mice exhibit overt myeloproliferative neoplasm

anemia ( J:204263 )

• in pIpC-treated mice

increased leukocyte cell number ( J:204263 )

• in pIpC-treated mice

increased neutrophil cell number ( J:204263 )

• in pIpC-treated mice

increased monocyte cell number ( J:204263 )

• in pIpC-treated mice

neoplasm

increased acute lymphoblastic leukemia incidence ( J:204263 )

• some pIpC-treated mice die prematurely from T lineage acute lymphoblastic leukemia

immune system

enlarged spleen ( J:174880 , J:204263 )

• marked splenomegaly 2 days after pIpC induction (J:174880)

• in pIpC-treated mice (J:204263)

abnormal myelopoiesis ( J:174880 )

• display a myeloproliferative phenotype 2 days after pIpC induction

myeloid hyperplasia ( J:204263 )

• all pIpC-treated mice exhibit overt myeloproliferative neoplasm

increased leukocyte cell number ( J:204263 )

• in pIpC-treated mice

increased neutrophil cell number ( J:204263 )

• in pIpC-treated mice

increased monocyte cell number ( J:204263 )

• in pIpC-treated mice

growth/size/body

enlarged spleen ( J:174880 , J:204263 )

• marked splenomegaly 2 days after pIpC induction (J:174880)

• in pIpC-treated mice (J:204263)

Allelic Composition	Nras^tm1Tyj/Nras^tm2.1Tyj Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (44 available)
Nras^tm2.1Tyj mutation (0 available); any Nras mutation (44 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:204263 )

N	• mice exhibit normal survival

hematopoietic system

hematopoietic system phenotype ( J:204263 )

N	• pIpC-treated mice exhibit normal hematological parameters • CFU-GM cells from pIpC-treated mice exhibit normal cytokine response

Allelic Composition	Nras^tm1Tyj/Nras⁺ Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (44 available)
Tg(Tyr-cre/ERT2)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin morphology ( J:198244 )

• mice painted with tamoxifen on to shaven back skin develop small paucicelluar nevi in the deep dermal and periadnexal regions of the skin

pigmentation

hyperpigmentation ( J:198244 )

• 50% of mice painted with tamoxifen on to shaven back skin at about 2 months of age exhibit weak darkening of the skin within 4 to 8 months

Allelic Composition	Nras^tm1Tyj/Nras⁺ Tg(Vil1-cre)20Syr/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (44 available)
Tg(Vil1-cre)20Syr mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:132357 )

• one week after exposure to 2.5% dextran sodium sulfate (DSS), colonic epithelium shows high resistance to the effects relative to wild-type and Kras mutant animals; sensitivity to DSS-induced apoptosis is strongly reduced

Allelic Composition	Nras^tm1Tyj/Nras^tm1Tyj Tg(Tyr-cre/ERT2)1Lru/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (44 available)
Tg(Tyr-cre/ERT2)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal skin morphology ( J:198244 )

• mice painted with tamoxifen on to shaven back skin develop large multicellular nevi in the deep dermal and periadnexal regions of the skin

pigmentation

hyperpigmentation ( J:198244 )

• mice painted with tamoxifen on to shaven back skin at about 2 months of age exhibit darkening of the skin within 4 to 8 months; darkening is more apparent in tamoxifen-treated areas but systemic effects are seen with darkening of the tails

neoplasm

neoplasm ( J:198244 )

N	• tamoxifen painted mice do not develop cutaneous melanoma, even after 24 months of tamoxifen-induced expression

Allelic Composition	Nras^tm1Tyj/Nras^tm1Tyj Tg(Tyr-cre)1Lru/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (44 available)
Tg(Tyr-cre)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal cranium morphology ( J:198244 )

• most mice develop increasing cranial perimeter or cranial deformity

cellular

abnormal melanocyte proliferation ( J:198244 )

• increase in proliferation of leptomeningeal pigmented melanocytes

behavior/neurological

abnormal behavior ( J:198244 )

• symptoms progress rapidly to akathisia and general malaise

hyperresponsive to tactile stimuli ( J:198244 )

• at a median age of 4 months

tremors ( J:198244 )

• seen at a median age of 4 months

impaired coordination ( J:198244 )

• mice exhibit incoordination at a median age of 4 months

abnormal gait ( J:198244 )

• mice show impaired gait at a median age of 4 months

mortality/aging

premature death ( J:198244 )

• mice die before 12 months of age

craniofacial

abnormal cranium morphology ( J:198244 )

• most mice develop increasing cranial perimeter or cranial deformity

integument

abnormal skin morphology ( J:198244 )

• mice develop benign paucicellular dermal melanocytic lesions resembling human blue nevi

pigmentation

abnormal melanocyte proliferation ( J:198244 )

• increase in proliferation of leptomeningeal pigmented melanocytes

abnormal leptomeninges pigmentation ( J:198244 )

• brains show darkening of the leptomeninges that follows the sulci and fissures, and is more prominent in the frontoparietal region

• increase in the number of pigmented melanocytes that follow the gyri and sulci and envelop the ventricles (melanocytosis)

abnormal melanocyte morphology ( J:198244 )

• hyperpigmented dendritic melanocytes are seen in 3 week old and adult mice, particularly between the collagen bundles of the reticular dermis and along the adnexae of the deep dermal layers

hyperpigmentation ( J:198244 )

• darkening of the skin, tails, paws, and snouts that is evident from day 1 and persists throughout life

neoplasm

increased melanoma incidence ( J:198244 )

• darkly pigmented areas in the brain are composed of large melanocytic lesions comprising pleomorphic cells that invade the brain parenchyma with tumor cells rapidly dividing, indicating primary melanoma of the central nervous system

• however, mice do not develop cutaneous melanoma or tumors in the uvea, hearts, or oral and genital mucosa

• tumor cells frequently present intracytoplasmic melanin

Allelic Composition	Nras^tm1Tyj/Nras⁺ Tg(Tyr-cre)1Lru/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (44 available)
Tg(Tyr-cre)1Lru mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:198244 )

• progress to akathisia and general malaise

hyperresponsive to tactile stimuli ( J:198244 )

• at a median age of 12.5 months

tremors ( J:198244 )

• seen at a median age of 12.5 months

impaired coordination ( J:198244 )

• mice exhibit incoordination at a median age of 12.5 months

abnormal gait ( J:198244 )

• mice show impaired gait at a median age of 12.5 months

skeleton

abnormal cranium morphology ( J:198244 )

• most mice develop increasing cranial perimeter or cranial deformity symptoms

mortality/aging

premature death ( J:198244 )

• mice begin to die around 6 months of age with about 25% surviving past 18 months of age

craniofacial

abnormal cranium morphology ( J:198244 )

• most mice develop increasing cranial perimeter or cranial deformity symptoms

pigmentation

hyperpigmentation ( J:198244 )

• darkening of the skin, tails, paws, and snouts that is evident from day 1 and persists throughout life, that is less pronounced than that in homozygotes

Allelic Composition	Nras^tm1Tyj/Nras⁺ Tg(Fabp1-cre)1Jig/0
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nras^tm1Tyj mutation (1 available); any Nras mutation (44 available)
Tg(Fabp1-cre)1Jig mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:132357 )

N	• expression of mutant Nras appears to have no effect on the histology of the colonic epithelium

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