Phenotypes associated with this allele

• Allele Symbol: Tg(Tek-CYSLTR2)4Fun
• Allele Name: transgene insertion 4, Colin D Funk
• Allele ID: MGI:3775831
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Tek-CYSLTR2)4Fun/0	B6.Cg-Tg(Tek-CYSLTR2)4Fun	MGI:3783676

Genotype
MGI:3783676

tg1

• Allelic Composition: Tg(Tek-CYSLTR2)4Fun/0
• Genetic Background: B6.Cg-Tg(Tek-CYSLTR2)4Fun

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal response to cardiac infarction ( J:132275 )

• the number of apoptotic nuclei in the peri-infarct region of the heart is 7-fold higher than in wild-type littermates 48 hours after reperfusion

• two weeks after reperfusion mice have significant thinning of the interventricular septum and increases in the time constant of isovolumic relaxation

increased myocardial infarct size ( J:132275 )

• infarction size is 114% greater than in non-transgenic controls after ischemia-reperfusion injury (I/R injury)

• the levels of creatine kinase and lactate dehydrogenase, biochemical markers of mycardial injury, were elevated 230% and 100% respectively in plasma after I/R injury compared to non-transgenic controls

• infarcted areas of the heart have more hemorrhaging with 2-fold more permeability of the coronary circulation in damaged areas compared wild-type littermates

homeostasis/metabolism

abnormal response to cardiac infarction ( J:132275 )

• the number of apoptotic nuclei in the peri-infarct region of the heart is 7-fold higher than in wild-type littermates 48 hours after reperfusion

• two weeks after reperfusion mice have significant thinning of the interventricular septum and increases in the time constant of isovolumic relaxation

increased myocardial infarct size ( J:132275 )

• infarction size is 114% greater than in non-transgenic controls after ischemia-reperfusion injury (I/R injury)

• the levels of creatine kinase and lactate dehydrogenase, biochemical markers of mycardial injury, were elevated 230% and 100% respectively in plasma after I/R injury compared to non-transgenic controls

• infarcted areas of the heart have more hemorrhaging with 2-fold more permeability of the coronary circulation in damaged areas compared wild-type littermates