Phenotypes associated with this allele

• Allele Symbol: Actl6b^tm1Grc
• Allele Name: targeted mutation 1, Gerald R Crabtree
• Allele ID: MGI:3775841
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Actl6b^tm1Grc/Actl6b^tm1Grc	involves: 129S6/SvEvTac * C57BL/6	MGI:3783724

Genotype
MGI:3783724

hm1

• Allelic Composition: Actl6b^tm1Grc/Actl6b^tm1Grc
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:132101 )

• mice are born at the expected Mendelian ratio, but most die within 2 days

• about 25% of the homozygous mutant mice survive beyond postnatal day 2 and about 12% survive to adulthood

behavior/neurological

hyperactivity ( J:132101 )

• mice that escape the perinatal lethality are extremely hyperactive

nervous system

decreased CNS synapse formation ( J:132101 )

• synapse formation was severely impaired in long-term low-density hippocampal neuron cultures derived from E18.5 brain

abnormal dendrite morphology ( J:132101 )

• a significant reduction in activity-dependent dendritic outgrowth and significantly shorter and less complex dendritic trees than controls in long-term low-density hippocampal neuron cultures derived from embryonic brain and in brain slices

abnormal myelination ( J:132101 )

• reduction in size of the myelinated axon bundles in P18 hippocampal cross section