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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Shhtm6Amc
targeted mutation 6, Andrew P McMahon
MGI:3775846
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Shhtm6Amc/Shhtm6Amc Not Specified MGI:3783756
cx2
 		Ptch1tm1Mps/Ptch1+
Shhtm6Amc/Shhtm6Amc 		involves: 129S1/Sv * 129X1/SvJ MGI:3783757


Genotype
MGI:3783756
hm1
Allelic
Composition		 Shhtm6Amc/Shhtm6Amc
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shhtm6Amc mutation (1 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:132152 )
• homozygous mice are still born and show defects consistent with reduced Shh signaling
• neural tube at E10.5 show all Shh-dependent neural progenitor domains resulting in normal induction of floor plate




Genotype
MGI:3783757
cx2
Allelic
Composition		 Ptch1tm1Mps/Ptch1+
Shhtm6Amc/Shhtm6Amc
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1tm1Mps mutation (2 available); any Ptch1 mutation (115 available)
Shhtm6Amc mutation (1 available); any Shh mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:132152 )
• significantly normalized the size of each neural progenitor domains and the gross phenotype of Shhtm6Amc/Shhtm6Amc homozygous mice
• authors did not mention whether the prenatal lethality phenotype found in Shhtm6Amc/Shhtm6Amc homozygous mice was rescued or not




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory