Phenotypes associated with this allele

• Allele Symbol: Sp6^tm1Yoya
• Allele Name: targeted mutation 1, Yoshihiko Yamada
• Allele ID: MGI:3775913
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sp6^tm1Yoya/Sp6^tm1Yoya	B6.129-Sp6^tm1Yoya	MGI:3784422

Genotype
MGI:3784422

hm1

• Allelic Composition: Sp6^tm1Yoya/Sp6^tm1Yoya
• Genetic Background: B6.129-Sp6^tm1Yoya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Defective tooth formation in Sp6^tm1Yoya/Sp6^tm1Yoya mice

skeleton

abnormal molar cusp morphology ( J:132157 )

• poorly developed cusps cause malocclusion

abnormal tooth development ( J:132157 )

• multiple branching of tooth germs and defects in differentiation of dental epithelium and mesenchyme

• expression studies reveal defects in both ameloblast and odontoblast differentiation

delayed tooth eruption ( J:132157 )

• incisors and molars of mutant mice are not erupted at the age of 3 weeks, in contrast to wild-type mice

abnormal tooth mineralization ( J:132157 )

• chalky color incisors, indicating a mineral defect

abnormal dentin morphology ( J:132157 )

• irregular dentinal tubule formation

absent enamel ( J:132157 )

• entire enamel structure is completely missing from incisor surface of 12-week-old mutant mice

supernumerary teeth ( J:132157 )

• an excess number of molars which increase with age

supernumerary incisors ( J:132157 )

• at later stages, incisors erupt with excess numbers in mutant mice

mortality/aging

decreased survivor rate ( J:132157 )

• about 20% of homozygous mutant mice die at about the age of 2 months for an unknown cause

premature death ( J:132157 )

• about 20% of homozygous mutant mice die at about the age of 2 months for an unknown cause

growth/size/body

abnormal molar cusp morphology ( J:132157 )

• poorly developed cusps cause malocclusion

abnormal tooth development ( J:132157 )

• multiple branching of tooth germs and defects in differentiation of dental epithelium and mesenchyme

• expression studies reveal defects in both ameloblast and odontoblast differentiation

delayed tooth eruption ( J:132157 )

• incisors and molars of mutant mice are not erupted at the age of 3 weeks, in contrast to wild-type mice

abnormal tooth mineralization ( J:132157 )

• chalky color incisors, indicating a mineral defect

abnormal dentin morphology ( J:132157 )

• irregular dentinal tubule formation

absent enamel ( J:132157 )

• entire enamel structure is completely missing from incisor surface of 12-week-old mutant mice

supernumerary teeth ( J:132157 )

• an excess number of molars which increase with age

supernumerary incisors ( J:132157 )

• at later stages, incisors erupt with excess numbers in mutant mice

decreased body size ( J:132157 )

• homozygous mice are viable, but significantly smaller than wild-type

craniofacial

abnormal molar cusp morphology ( J:132157 )

• poorly developed cusps cause malocclusion

abnormal tooth development ( J:132157 )

• multiple branching of tooth germs and defects in differentiation of dental epithelium and mesenchyme

• expression studies reveal defects in both ameloblast and odontoblast differentiation

delayed tooth eruption ( J:132157 )

• incisors and molars of mutant mice are not erupted at the age of 3 weeks, in contrast to wild-type mice

abnormal tooth mineralization ( J:132157 )

• chalky color incisors, indicating a mineral defect

abnormal dentin morphology ( J:132157 )

• irregular dentinal tubule formation

absent enamel ( J:132157 )

• entire enamel structure is completely missing from incisor surface of 12-week-old mutant mice

supernumerary teeth ( J:132157 )

• an excess number of molars which increase with age

supernumerary incisors ( J:132157 )

• at later stages, incisors erupt with excess numbers in mutant mice