Phenotypes associated with this allele

• Allele Symbol: Gpr50^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:3775916
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr50^tm1Dgen/Gpr50^tm1Dgen	involves: C57BL/6	MGI:3811204

Genotype
MGI:3811204

hm1

• Allelic Composition: Gpr50^tm1Dgen/Gpr50^tm1Dgen
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

abnormal postnatal growth/weight/body size ( J:131227 )

♀ • slower weight gain over from weaning to 10 weeks of age but for 5 weeks after this weight gain is similar to controls

slow postnatal weight gain ( J:131227 )

♀ • slower weight gain over from weaning to 10 weeks of age but for 5 weeks after this weight gain is similar to controls

decreased susceptibility to diet-induced obesity ( J:131227 )

♀ • gain less weight when fed a high energy diet for 5 weeks

♀ • about 70% of the weight difference compared to controls is due to a decrease in percentage of body fat

adipose tissue

decreased percent body fat/body weight ( J:131227 )

♀ • on a high energy diet body fat percentage is 31.9 +/- 2.1% compared to 39.1 +/- 1.4% in wild-type controls

behavior/neurological

increased food intake ( J:131227 )

♀ • consume more food per unit body weight

hyperactivity ( J:131227 )

♀ • significant increase in activity in the light phase and over the total 24 h period

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:131227 )

♀ • gain less weight when fed a high energy diet for 5 weeks

♀ • about 70% of the weight difference compared to controls is due to a decrease in percentage of body fat

increased carbon dioxide production ( J:131227 )

♀ • significantly higher during the light phase

increased oxygen consumption ( J:131227 )

♀ • significantly higher during the light phase