Phenotypes associated with this allele

• Allele Symbol: Ip6k1^tm1.1Snyd
• Allele Name: targeted mutation 1.1, Solomon Snyder
• Allele ID: MGI:3775918
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ip6k1^tm1.1Snyd/Ip6k1^tm1.1Snyd	involves: 129X1/SvJ * BALB/c * C57BL/6	MGI:3801298

Genotype
MGI:3801298

hm1

• Allelic Composition: Ip6k1^tm1.1Snyd/Ip6k1^tm1.1Snyd
• Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Impaired spermiogenesis in Ip6k1^tm1.1Snyd/Ip6k1^tm1.1Snyd mice

growth/size/body

decreased body size ( J:132167 )

• smaller body size despite normal food intake

postnatal growth retardation ( J:132167 )

homeostasis/metabolism

decreased circulating insulin level ( J:132167 )

• 60-70% reduction in circulating insulin

• despite low insulin levels, mutants are not diabetic and display normal blood glucose levels, normal glucose tolerance, and have normal levels of glycosylated hemoglobin

increased insulin sensitivity ( J:132167 )

• mutants exhibit a greater diminution of blood glucose levels in response to insulin than controls

reproductive system

azoospermia ( J:132167 )

♂ • mutants exhibit very few advanced spermatids in the seminiferous tubules and no sperm in the epidiymis

abnormal spermatid morphology ( J:132167 )

♂ • mutants exhibit very few advanced spermatids in the seminiferous tubules

abnormal spermiogenesis ( J:132167 )

♂ • defect in spermiogenesis, in the final stage of spermatogenesis during which round spermatids develop into mature, motile spermatozoa

male infertility ( J:132167 )

♂

cellular

azoospermia ( J:132167 )

♂ • mutants exhibit very few advanced spermatids in the seminiferous tubules and no sperm in the epidiymis

abnormal spermatid morphology ( J:132167 )

♂ • mutants exhibit very few advanced spermatids in the seminiferous tubules