Phenotypes associated with this allele

• Allele Symbol: Ikbkg^tm1Dwb
• Allele Name: targeted mutation 1, Dean Ballard
• Allele ID: MGI:3775942
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ikbkg^tm1Dwb/Ikbkg^tm1Dwb	Not Specified	MGI:3797724

Genotype
MGI:3797724

hm1

• Allelic Composition: Ikbkg^tm1Dwb/Ikbkg^tm1Dwb
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal humoral immune response ( J:136353 )

♀ • mice exhibit an attenuated humoral response following injection with KLH unlike wild-type mice

abnormal chemokine secretion ( J:136353 )

♀ • following treatment with LPS, macrophages produce modestly less MCP-1 than wild-type mice

decreased interleukin-12b secretion ( J:136353 )

♀ • following treatment with LPS or TLR agonists, macrophages and bone marrow dendritic cells produce less IL-12b than wild-type mice

♀ • however, stimulation of bone marrow dendritic cells with high levels of LPS elicits a normal response

decreased interleukin-6 secretion ( J:136353 )

♀ • following treatment with LPS or TLR agonists, macrophages and bone marrow dendritic cells produce less IL-6 than wild-type mice

♀ • however, stimulation of bone marrow dendritic cells with high levels of LPS elicits a normal response

decreased tumor necrosis factor secretion ( J:136353 )

♀ • following treatment with LPS, macrophages and bone marrow dendritic cells produce modestly less TNF than wild-type mice

♀ • however, stimulation of bone marrow dendritic cells with high levels of LPS elicits a normal response

decreased susceptibility to endotoxin shock ( J:136353 )

♀ • mice are resistant to LPS -induced shock with decreased mortality and production of TNF, IL-6 and IFN-gamma compared to wild-type mice