Analysis Tools
mortality/aging
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• increased death rate beginning at 3-4 months of age
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• increased death rate beginning at 3-4 months of age
• during the first 18 months of the study, 23% of mutants died compared to 0% of wild-type
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reproductive system
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• testes have high numbers of atrophic seminiferous tubules
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neoplasm
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• females exhibit a high incidence of spontaneous B-cell lymphomas
• lymphomas are more invasive than the few lymphomas that develop in wild-type females, and show a high degree of infiltration of multiple organs such as pancreas and mesenteric lymph nodes
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• females exhibit an increase in the incidence of malignant neoplasias
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endocrine/exocrine glands
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• testes have high numbers of atrophic seminiferous tubules
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