All Phenotypes Flvcr1<tm1.1Jlab> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Flvcr1^tm1.1Jlab/Flvcr1^tm1.1Jlab	B6.129S4-Flvcr1^tm1.1Jlab	MGI:3807531
hm2	Flvcr1^tm1.1Jlab/Flvcr1^tm1.1Jlab	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:3807528
ht3	Flvcr1^tm1.1Jlab/Flvcr1⁺	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:3807527

Allelic Composition	Flvcr1^tm1.1Jlab/Flvcr1^tm1.1Jlab
Genetic Background	B6.129S4-Flvcr1^tm1.1Jlab

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flvcr1^tm1.1Jlab mutation (0 available); any Flvcr1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:132057 )

• Background Sensitivity: dead but morphologically identifiable homozygous embryos are found E12.5, while on a mixed background, mutants surviving past E7.5 are alive and indistinguishable from littermates at E12.5

limbs/digits/tail

abnormal limb development ( J:132057 )

• Background Sensitivity: limbs are abnormal but this phenotype is less apparent than on a mixed background and when death occurs prior to E14.5

craniofacial

abnormal craniofacial morphology ( J:132057 )

• Background Sensitivity: defects are observed but are less apparent than on mixed background and when death occurs prior to E14.5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

enlarged heart ( J:132057 )

• cardiomegaly observed upon necropsy at 4-6 weeks, after cre induction at 1 week postnatal

decreased body size ( J:132057 )

• by 4 weeks of age, mice are runted, after cre induction at 1 week postnatal

enlarged spleen ( J:132057 )

• observed upon necropsy at 4-6 weeks, after cre induction at 1 week postnatal

cardiovascular system

enlarged heart ( J:132057 )

• cardiomegaly observed upon necropsy at 4-6 weeks, after cre induction at 1 week postnatal

hematopoietic system

abnormal erythropoiesis ( J:132057 )

• bone marrow shows block in erythroid maturation at proerythroblast stage; this is also observed in liver and spleen

anemia ( J:132057 )

• mice develop pure red cell aplasia (PRCA)

hyperchromic macrocytic anemia ( J:132057 )

• observed at 6 weeks of age, following cre induction at 1 week postnatal

reticulocytopenia ( J:132057 )

• mice show reticulocytopenia by 6 weeks of age, following cre induction at 1 week postnatal

abnormal spleen morphology ( J:132057 )

• enlarged spleens have expanded interfollicular regions

enlarged spleen ( J:132057 )

• observed upon necropsy at 4-6 weeks, after cre induction at 1 week postnatal

immune system

abnormal spleen morphology ( J:132057 )

• enlarged spleens have expanded interfollicular regions

enlarged spleen ( J:132057 )

• observed upon necropsy at 4-6 weeks, after cre induction at 1 week postnatal

limbs/digits/tail

abnormal autopod morphology ( J:132057 )

• by 4 weeks of age, mice have pale paws, after cre induction at 1 week postnatal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Diamond-Blackfan anemia		DOID:1339	OMIM:PS105650	J:132057

Allelic Composition	Flvcr1^tm1.1Jlab/Flvcr1⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flvcr1^tm1.1Jlab mutation (0 available); any Flvcr1 mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:132057 )

• indistinguishable from controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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