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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(ptxA)Cgh
targeted mutation 1, Shaun R Coughlin
MGI:3776029
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sortm1(ptxA)Cgh involves: 129P2/OlaHsd * C57BL/6 MGI:3784870
cn2
 		Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Rac1tm1Djk/Rac1tm1Djk 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL MGI:4438086
cn3
 		Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Tg(Pdx1-cre)6Cvw/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3784869
cn4
 		Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Tg(Ins2-cre)25Mgn/0 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:3784868
cn5
 		Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:4431053
cn6
 		Gnaztm1Lfb/Gnaztm1Lfb
Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:4438084
cn7
 		Gnaztm1Lfb/Gnaz+
Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:4438085


Genotype
MGI:3784870
hm1
Allelic
Composition		 Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sortm1(ptxA)Cgh
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (994 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:130781 )
• mice are indistinguishable from wild-type mice




Genotype
MGI:4438086
cn2
Allelic
Composition		 Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Rac1tm1Djk/Rac1tm1Djk
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Gt(ROSA)26Sortm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (994 available)
Rac1tm1Djk mutation (1 available); any Rac1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
spina bifida ( J:157446 )
• observed in about 58% of viable embryos collected at 14.5 days post coitus
• folate injections performed on pregnant females does not affect penetrance

nervous system
spina bifida ( J:157446 )
• observed in about 58% of viable embryos collected at 14.5 days post coitus
• folate injections performed on pregnant females does not affect penetrance
exencephaly ( J:157446 )
• observed with around 83% frequency in viable embryos collected at 14.5 days post coitus
• folate injections performed on pregnant females does not affect penetrance




Genotype
MGI:3784869
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Tg(Pdx1-cre)6Cvw/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (994 available)
Tg(Pdx1-cre)6Cvw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
improved glucose tolerance ( J:130781 )
• glucose clearance is increased compared to in wild-type mice




Genotype
MGI:3784868
cn4
Allelic
Composition		 Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Tg(Ins2-cre)25Mgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (994 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal glucose homeostasis ( J:130781 )
• unlike in wild-type mice, glucose and insulin levels are unresponsive to treatment with 3-iodothyronamine
increased circulating insulin level ( J:130781 )
• plasma insulin levels are 4- to 5-fold higher than in wild-type mice
• plasma insulin levels following administration of glucose increased 6.5-fold over basal levels compared to an increase of only 3-fold in similarly treated wild-type mice and peak insulin level achieved is 15-fold higher than in similarly treated wild-type mice
improved glucose tolerance ( J:130781 )
• glucose clearance is increased compared to in wild-type mice
• when fed a high fat diet, mice exhibit improved glucose tolerance and normal fasting blood glucose levels compared to wild-type mice
• unlike wild-type mice, treatment with SLIGRL does not alter plasma glucose levels

endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:130781 )
N
• despite altered glucose homeostasis, mice exhibit normal pancreatic islet cell size, number, histological appearance and cellular composition




Genotype
MGI:4431053
cn5
Allelic
Composition		 Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl3tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Gt(ROSA)26Sortm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (994 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal neural tube closure ( J:157446 )
• some embryos have open hindbrain neuropores, but open posterior neuropores (spina bifida) are not seen

nervous system
abnormal neural tube closure ( J:157446 )
• some embryos have open hindbrain neuropores, but open posterior neuropores (spina bifida) are not seen
exencephaly ( J:157446 )
• observed with 10% frequency in viable embryos collected at 14.5 days post coitus




Genotype
MGI:4438084
cn6
Allelic
Composition		 Gnaztm1Lfb/Gnaztm1Lfb
Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnaztm1Lfb mutation (1 available); any Gnaz mutation (18 available)
Grhl3tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Gt(ROSA)26Sortm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (994 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
spina bifida ( J:157446 )
• observed in about 40% of embryos collected at 14.5 days post coitus

nervous system
spina bifida ( J:157446 )
• observed in about 40% of embryos collected at 14.5 days post coitus
exencephaly ( J:157446 )
• observed with 20% frequency at 14.5 days post coitus; no embryos




Genotype
MGI:4438085
cn7
Allelic
Composition		 Gnaztm1Lfb/Gnaz+
Grhl3tm1(cre)Cgh/Grhl3+
Gt(ROSA)26Sortm1(ptxA)Cgh/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnaztm1Lfb mutation (1 available); any Gnaz mutation (18 available)
Grhl3tm1(cre)Cgh mutation (1 available); any Grhl3 mutation (53 available)
Gt(ROSA)26Sortm1(ptxA)Cgh mutation (1 available); any Gt(ROSA)26Sor mutation (994 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
spina bifida ( J:157446 )
• observed in about 18% of viable embryos collected at 14.5 days post coitus
exencephaly ( J:157446 )
• observed with around 4% frequency in viable embryos collected at 14.5 days post coitus

embryo
spina bifida ( J:157446 )
• observed in about 18% of viable embryos collected at 14.5 days post coitus




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory