Phenotypes associated with this allele

• Allele Symbol: Dll1^tm2Gos
• Allele Name: targeted mutation 2, Achim Gossler
• Allele ID: MGI:3776424
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dll1^tm1Gos/Dll1^tm2Gos	involves: 129S1/Sv * 129X1/SvJ	MGI:3848986
ht2	Dll1^tm1Gos/Dll1^tm2Gos	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3776428
cx3	Dll1^tm1Gos/Dll1^tm2Gos Jag2^tm1Grid/Jag2^tm1Grid	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J	MGI:3776435
cx4	Dll1^tm2Gos/Dll1^+ Jag2^tm1Grid/Jag2^+	involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J	MGI:3776430

Genotype
MGI:3848986

ht1

• Allelic Composition: Dll1^tm1Gos/Dll1^tm2Gos
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:148902 )

cardiovascular system

artery stenosis ( J:148902 )

• lumens of large arteries show a reduction in diameters at E18.5, with no significant differences in arterial wall thickness

aorta stenosis ( J:148902 )

• lumen shows a reduction in diameter compared to controls

abnormal capillary branching pattern ( J:148902 )

• significant increase in capillary branch points in the skin is observed at E17.5

abnormal skin vasculature morphology ( J:148902 )

• significant increase in capillary branch points in the skin is observed at E17.5

muscle

abnormal muscle morphology ( J:148902 )

abnormal myogenesis ( J:148902 )

decreased skeletal muscle mass ( J:148902 )

integument

abnormal skin vasculature morphology ( J:148902 )

• significant increase in capillary branch points in the skin is observed at E17.5

Genotype
MGI:3776428

ht2

• Allelic Composition: Dll1^tm1Gos/Dll1^tm2Gos
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

mortality/aging

perinatal lethality, complete penetrance ( J:119082 )

• mice survive until birth

• mice do not survive postnatally

• however, mice survive beyond E10.5 when Dll1^tm1Gos homozygotes die

cellular

abnormal myoblast differentiation ( J:119082 )

• progenitor cells are lost due to premature differentiation and not an increase in apoptosis

• dermomyotome-derived myoblasts differentiate more rapidly than in wild-type mice

abnormal myotube differentiation ( J:119082 )

• beginning at E14.5, the number of secondary myotubes are severely reduced

muscle

abnormal myoblast differentiation ( J:119082 )

• progenitor cells are lost due to premature differentiation and not an increase in apoptosis

• dermomyotome-derived myoblasts differentiate more rapidly than in wild-type mice

abnormal myotube differentiation ( J:119082 )

• beginning at E14.5, the number of secondary myotubes are severely reduced

decreased skeletal muscle mass ( J:119082 )

• at E13.5, skeletal muscle is hypotrophied

• at E18.5, skeletal muscle is severely reduced

behavior/neurological

no spontaneous movement ( J:119082 )

• mice are motionless at E18.5

embryo

abnormal somite development ( J:132241 )

• mice exhibit defects in segmentation due to disrupted somitogenesis

skeleton

abnormal axial skeleton morphology ( J:119082 )

growth/size/body

decreased body length ( J:119082 )

Genotype
MGI:3776435

cx3

• Allelic Composition: Dll1^tm1Gos/Dll1^tm2Gos; Jag2^tm1Grid/Jag2^tm1Grid
• Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6J

hearing/vestibular/ear

abnormal organ of Corti morphology ( J:132241 )

• unlike in wild-type mice, cells within the organ of Corti continue to proliferate between E14.5 and E17.5

abnormal cochlear hair cell morphology ( J:132241 )

• hair cells are disorganized and very densely packed

increased cochlear inner hair cell number ( J:132241 )

• cochlea exhibit a greater increase in inner hair cells than in Jag2^tm1Grid homozygotes

increased cochlear outer hair cell number ( J:132241 )

abnormal orientation of cochlear hair cell stereociliary bundles ( J:132241 )

• hair cell stereocilia bundles exhibit a lose of polarity and disorganization

decreased organ of Corti supporting cell number ( J:132241 )

• many of the missing supporting cells are derived from the Deiter's cell population

nervous system

abnormal cochlear hair cell morphology ( J:132241 )

• hair cells are disorganized and very densely packed

increased cochlear inner hair cell number ( J:132241 )

• cochlea exhibit a greater increase in inner hair cells than in Jag2^tm1Grid homozygotes

increased cochlear outer hair cell number ( J:132241 )

abnormal orientation of cochlear hair cell stereociliary bundles ( J:132241 )

• hair cell stereocilia bundles exhibit a lose of polarity and disorganization

Genotype
MGI:3776430

cx4

• Allelic Composition: Dll1^tm2Gos/Dll1⁺; Jag2^tm1Grid/Jag2⁺
• Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

hearing/vestibular/ear

increased cochlear inner hair cell number ( J:132241 )

• cochlea possess increased inner hair cells but not as many as in Jag2^tm1Grid homozygotes

increased cochlear outer hair cell number ( J:132241 )

nervous system

increased cochlear inner hair cell number ( J:132241 )

• cochlea possess increased inner hair cells but not as many as in Jag2^tm1Grid homozygotes

increased cochlear outer hair cell number ( J:132241 )