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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aplntm1Tq
targeted mutation 1, Thomas Quertermous
MGI:3776530
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Aplntm1Tq/Aplntm1Tq B6.129S6-Aplntm1Tq MGI:4367883
ot2
 		Aplntm1Tq/Y B6.129S6-Aplntm1Tq MGI:4367886


Genotype
MGI:4367883
hm1
Allelic
Composition		 Aplntm1Tq/Aplntm1Tq
Genetic
Background		 B6.129S6-Aplntm1Tq
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplntm1Tq mutation (0 available); any Apln mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased cardiac muscle contractility ( J:154303 )
• mice exhibit lower end-systolic pressure volume relationship compared with wild-type mice
abnormal myocardial fiber physiology ( J:154303 )
• cardiomyocyte sarcomeric function is decreased with impaired velocity of contraction and relaxation compared to in wild-type mice
• however, intracellular calcium is unchanged

homeostasis/metabolism
impaired exercise endurance ( J:154303 )
• mice exhibit decreased exercise endurance compared with wild-type mice
decreased oxygen consumption ( J:154303 )
• mice exhibit reduced maximal oxygen consumption compared with wild-type mice

muscle
decreased cardiac muscle contractility ( J:154303 )
• mice exhibit lower end-systolic pressure volume relationship compared with wild-type mice

behavior/neurological
impaired exercise endurance ( J:154303 )
• mice exhibit decreased exercise endurance compared with wild-type mice




Genotype
MGI:4367886
ot2
Allelic
Composition		 Aplntm1Tq/Y
Genetic
Background		 B6.129S6-Aplntm1Tq
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplntm1Tq mutation (0 available); any Apln mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased cardiac muscle contractility ( J:154303 )
• mice exhibit lower end-systolic pressure volume relationship compared with wild-type mice
abnormal myocardial fiber physiology ( J:154303 )
• cardiomyocyte sarcomeric function is decreased with impaired velocity of contraction and relaxation compared to in wild-type mice
• however, intracellular calcium is unchanged

homeostasis/metabolism
impaired exercise endurance ( J:154303 )
• mice exhibit decreased exercise endurance compared with wild-type mice
decreased oxygen consumption ( J:154303 )
• mice exhibit reduced maximal oxygen consumption compared with wild-type mice

muscle
decreased cardiac muscle contractility ( J:154303 )
• mice exhibit lower end-systolic pressure volume relationship compared with wild-type mice

behavior/neurological
impaired exercise endurance ( J:154303 )
• mice exhibit decreased exercise endurance compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory