About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Aplntm1Tq
targeted mutation 1, Thomas Quertermous
MGI:3776530
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Aplntm1Tq/Aplntm1Tq B6.129S6-Aplntm1Tq MGI:4367883
ot2
 		Aplntm1Tq/Y B6.129S6-Aplntm1Tq MGI:4367886


Genotype
MGI:4367883
hm1
Allelic
Composition		 Aplntm1Tq/Aplntm1Tq
Genetic
Background		 B6.129S6-Aplntm1Tq
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplntm1Tq mutation (0 available); any Apln mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased cardiac muscle contractility ( J:154303 )
• mice exhibit lower end-systolic pressure volume relationship compared with wild-type mice
abnormal myocardial fiber physiology ( J:154303 )
• cardiomyocyte sarcomeric function is decreased with impaired velocity of contraction and relaxation compared to in wild-type mice
• however, intracellular calcium is unchanged

homeostasis/metabolism
impaired exercise endurance ( J:154303 )
• mice exhibit decreased exercise endurance compared with wild-type mice
decreased oxygen consumption ( J:154303 )
• mice exhibit reduced maximal oxygen consumption compared with wild-type mice

muscle
decreased cardiac muscle contractility ( J:154303 )
• mice exhibit lower end-systolic pressure volume relationship compared with wild-type mice

behavior/neurological
impaired exercise endurance ( J:154303 )
• mice exhibit decreased exercise endurance compared with wild-type mice




Genotype
MGI:4367886
ot2
Allelic
Composition		 Aplntm1Tq/Y
Genetic
Background		 B6.129S6-Aplntm1Tq
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplntm1Tq mutation (0 available); any Apln mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased cardiac muscle contractility ( J:154303 )
• mice exhibit lower end-systolic pressure volume relationship compared with wild-type mice
abnormal myocardial fiber physiology ( J:154303 )
• cardiomyocyte sarcomeric function is decreased with impaired velocity of contraction and relaxation compared to in wild-type mice
• however, intracellular calcium is unchanged

homeostasis/metabolism
impaired exercise endurance ( J:154303 )
• mice exhibit decreased exercise endurance compared with wild-type mice
decreased oxygen consumption ( J:154303 )
• mice exhibit reduced maximal oxygen consumption compared with wild-type mice

muscle
decreased cardiac muscle contractility ( J:154303 )
• mice exhibit lower end-systolic pressure volume relationship compared with wild-type mice

behavior/neurological
impaired exercise endurance ( J:154303 )
• mice exhibit decreased exercise endurance compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory