Phenotypes associated with this allele

• Allele Symbol: Slamf1^tm1Oono
• Allele Name: targeted mutation 1, Shinji Ohno
• Allele ID: MGI:3776761
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slamf1^tm1Oono/Slamf1^tm1Oono	B6.129-Slamf1^tm1Oono	MGI:3777088
cx2	Ifnar1^tm1Agt/Ifnar1^tm1Agt Slamf1^tm1Oono/Slamf1^tm1Oono	B6.129-Slamf1^tm1Oono Ifnar1^tm1Agt	MGI:3777089

Genotype
MGI:3777088

hm1

• Allelic Composition: Slamf1^tm1Oono/Slamf1^tm1Oono
• Genetic Background: B6.129-Slamf1^tm1Oono

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to Paramyxoviridae infection ( J:117810 )

• splenocytes and DCs from the mutant mice permitted IC-B strain measle virus entry and replication in vitro, however, measle virus growth was not supported in vivo

• normal level of IL-4 and IFN-gamma from CD4+

• normal production of TNF-alpha and NO from peritoneal macrophages

• normal cellular composition of splenocytes

Genotype
MGI:3777089

cx2

• Allelic Composition: Ifnar1^tm1Agt/Ifnar1^tm1Agt; Slamf1^tm1Oono/Slamf1^tm1Oono
• Genetic Background: B6.129-Slamf1^tm1Oono Ifnar1^tm1Agt

immune system

abnormal lymphopoiesis ( J:117810 )

• lymphocytes from measle virus infected double mutant show proliferation inhibition when stimulated with ConA

increased susceptibility to Paramyxoviridae infection ( J:117810 )

• double mutant mice permitted the in vivo growth of measle virus after i.p. or intranasal inoculation, however, on the contrary to expectation, growth of IC-B strain measle virus was not enhanced in splenocytes form double mutant compared with those from the single mutant, Ifnar1⁺/Ifnar1⁺, Slamf1^tm1Oono/Slamf1^tm1Oono, splenocytes

hematopoietic system

abnormal lymphopoiesis ( J:117810 )

• lymphocytes from measle virus infected double mutant show proliferation inhibition when stimulated with ConA