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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcf3tm1Xhsu
targeted mutation 1, Xioa-Hong Sun
MGI:3776793
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcf3tm1Xhsu/Tcf3tm1Xhsu B6.129X1-Tcf3tm1Xhsu MGI:3776806
cx2
 		Tcf3tm1Xhsu/Tcf3tm1Xhsu
Tg(Lck-Stat5b*)1Mafa/0 		involves: 129X1/SvJ * C57BL/6 * FVB/N MGI:3776807


Genotype
MGI:3776806
hm1
Allelic
Composition		 Tcf3tm1Xhsu/Tcf3tm1Xhsu
Genetic
Background		 B6.129X1-Tcf3tm1Xhsu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1Xhsu mutation (0 available); any Tcf3 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:132669 )
N
• T-cell development is normal
increased B cell number ( J:132669 )
• at 2 months of age the number of CD19+ IgM- and CD19+ IgM+ B cells is increased compared to in wild-type mice

hematopoietic system
increased B cell number ( J:132669 )
• at 2 months of age the number of CD19+ IgM- and CD19+ IgM+ B cells is increased compared to in wild-type mice




Genotype
MGI:3776807
cx2
Allelic
Composition		 Tcf3tm1Xhsu/Tcf3tm1Xhsu
Tg(Lck-Stat5b*)1Mafa/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1Xhsu mutation (0 available); any Tcf3 mutation (43 available)
Tg(Lck-Stat5b*)1Mafa mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell proliferation ( J:132669 )
• B cell proliferation is increased
• however, unlike in mice expressing the transgene alone, B cell maturation in bone marrow and thymus is restored

hematopoietic system
increased B cell proliferation ( J:132669 )
• B cell proliferation is increased
• however, unlike in mice expressing the transgene alone, B cell maturation in bone marrow and thymus is restored

cellular
increased B cell proliferation ( J:132669 )
• B cell proliferation is increased
• however, unlike in mice expressing the transgene alone, B cell maturation in bone marrow and thymus is restored




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory