About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hdac6tm1.1Pmt
targeted mutation 1.1, Patrick Matthias
MGI:3776868
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hdac6tm1.1Pmt/Hdac6tm1.1Pmt involves: 129P2/OlaHsd MGI:5708043
hm2
 		Hdac6tm1.1Pmt/Hdac6tm1.1Pmt involves: 129P2/OlaHsd * C57BL/6 MGI:3810640
cx3
 		Hdac6tm1.1Pmt/Y
Tg(SOD1*G93A)1Gur/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL MGI:5499285
ot4
 		Hdac6tm1.1Pmt/Y involves: 129P2/OlaHsd * C57BL/6 MGI:5499210


Genotype
MGI:5708043
hm1
Allelic
Composition		 Hdac6tm1.1Pmt/Hdac6tm1.1Pmt
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac6tm1.1Pmt mutation (0 available); any Hdac6 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-10 secretion ( J:228570 )
• from peritoneal elicited macrophages (PEM) and dendritic cells in response to LPS

homeostasis/metabolism




Genotype
MGI:3810640
hm2
Allelic
Composition		 Hdac6tm1.1Pmt/Hdac6tm1.1Pmt
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac6tm1.1Pmt mutation (0 available); any Hdac6 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:132629 )
N
• mice are fertile and exhibit normal fertilization

immune system
immune system phenotype ( J:132629 )
N
• despite modest effects to immune response, mice exhibit normal lymphocyte develpment
decreased IgG level ( J:132629 )
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice
decreased IgM level ( J:132629 )
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice

skeleton
increased bone mineral content ( J:132629 )
• tibial bone mineral content is slightly increased at 3 months compared to wild-type mice
increased bone mineral density ( J:132629 )
• cancellous bone mineral density is moderately increased compared to wild-type mice
• however, after 3 months bone mineral density is normal

growth/size/body
increased body weight ( J:132629 )
• at 3 months

nervous system
nervous system phenotype ( J:132629 )
N
• mice exhibit normal brain and spinal cord morphology

hematopoietic system
decreased IgG level ( J:132629 )
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice
decreased IgM level ( J:132629 )
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice




Genotype
MGI:5499285
cx3
Allelic
Composition		 Hdac6tm1.1Pmt/Y
Tg(SOD1*G93A)1Gur/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac6tm1.1Pmt mutation (0 available); any Hdac6 mutation (17 available)
Tg(SOD1*G93A)1Gur mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
abnormal survival ( J:194977 )
• modest increase in survival compared with Tg(SOD1*G93A)1Gur mice

nervous system
abnormal innervation pattern to muscle ( J:194977 )
• NMJ innervation of the gastrocnemius muscle is improved compared to in Tg(SOD1*G93A)1Gur mice
increased neuron number ( J:194977 )
• in the ventral horn compared to in Tg(SOD1*G93A)1Gur mice with more pronounced protection of large neurons
abnormal action potential ( J:194977 )
• mice exhibit higher compound action potential amplitudes compared with Tg(SOD1*G93A)1Gur mice

behavior/neurological
decreased grip strength ( J:194977 )
• same age of onset as in Tg(SOD1*G93A)1Gur mice




Genotype
MGI:5499210
ot4
Allelic
Composition		 Hdac6tm1.1Pmt/Y
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac6tm1.1Pmt mutation (0 available); any Hdac6 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:132629 )
N
• mice are fertile and exhibit normal fertilization

immune system
immune system phenotype ( J:132629 )
N
• despite modest effects to immune response, mice exhibit normal lymphocyte develpment
decreased IgG level ( J:132629 )
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice
decreased IgM level ( J:132629 )
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice

skeleton
increased bone mineral content ( J:132629 )
• tibial bone mineral content is slightly increased at 3 months compared to wild-type mice
increased bone mineral density ( J:132629 )
• cancellous bone mineral density is moderately increased compared to wild-type mice
• however, after 3 months bone mineral density is normal

growth/size/body
increased body weight ( J:132629 )
• at 3 months

nervous system
nervous system phenotype ( J:132629 )
N
• mice exhibit normal brain and spinal cord morphology

hematopoietic system
decreased IgG level ( J:132629 )
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice
decreased IgM level ( J:132629 )
• mice exhibit decreased IgM and IgG levels in response to immunization with DNP-KLH compared to wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory