Phenotypes associated with this allele

• Allele Symbol: Tjp2^tm1Whun
• Allele Name: targeted mutation 1, Walter Hunziker
• Allele ID: MGI:3776874
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tjp2^tm1Whun/Tjp2^tm1Whun	either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)	MGI:3794417

Genotype
MGI:3794417

hm1

• Allelic Composition: Tjp2^tm1Whun/Tjp2^tm1Whun
• Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:132649 )

• mutants die shortly after implantation due to an arrest in early gastrulation

growth/size/body

decreased embryo size ( J:132649 )

• by E7.5, embryos are less than half the size of wild-type or heterozygotes

embryo

increased embryonic tissue cell apoptosis ( J:132649 )

• embryos show increased apoptosis at E7.5

failure to gastrulate ( J:132649 )

• arrest in early gastrulation

embryonic growth arrest ( J:132649 )

• arrest in early gastrulation and fail to develop past the egg cylinder stage

decreased embryo size ( J:132649 )

• by E7.5, embryos are less than half the size of wild-type or heterozygotes

absent mesoderm ( J:132649 )

• egg cylinders are composed of discreet ectoderm and endoderm cell layers but do not show evidence of mesoderm development

disorganized embryonic tissue ( J:132649 )

• general embryo disorganization is seen by E7.5

cellular

abnormal plasma membrane morphology ( J:132649 )

• paracellular permeability of a low-molecular weight tracer is increased in embryos, indicating leaky tight junctions

• structure and permeability barrier of the apical junctional complex are altered in cells

increased embryonic tissue cell apoptosis ( J:132649 )

• embryos show increased apoptosis at E7.5

decreased cell proliferation ( J:132649 )

• embryos show decreased proliferation at E6.5