All Phenotypes Ovol2<tm1Sito> MGI Mouse

embryonic lethality during organogenesis, complete penetrance ( J:132526 )

• embryos die in utero between E9.5 and E10.5, due to abnormal cardiovascular development

embryonic growth retardation ( J:132526 )

• at E8.5 and E9.5

decreased embryo size ( J:132526 )

• at E9.5, embryos are smaller than wild-type

abnormal embryonic tissue morphology ( J:132526 )

absent pharyngeal arches ( J:132526 )

• at E9.5, only first branchial arch is observed in mutants, not three

open neural tube ( J:132526 )

• at E9.5 embryos display open head folds

abnormal extraembryonic tissue morphology ( J:132526 )

abnormal placenta vasculature ( J:132526 )

• mutant embryos show normal establishment of allantoic vessels and differentiation of trophoblast cells, but fail to support normal branching or elongation of the vessels and labyrinthine layer in the placenta

abnormal placental labyrinth vasculature morphology ( J:132526 )

• at E9.5, the invasion of allantoic vessels into the labyrinth layer and the number of fetal blood cells are reduced in the mutant placenta

• at E10.5, the invasion process is retracted, and only a few fetal blood cells are found in the chorion

abnormal vitelline vasculature morphology ( J:132526 )

absent vitelline blood vessels ( J:132526 )

• at E9.5, yolk sac fails to develop large vitelline vessels

abnormal vitelline vascular remodeling ( J:132526 )

• at E9.5, vascular remodeling in the yolk sac does not occur

• at E9.5, mutant yolk sacs display the same primary vascular plexus observed at E8.5

embryonic growth retardation ( J:132526 )

• at E8.5 and E9.5

decreased embryo size ( J:132526 )

• at E9.5, embryos are smaller than wild-type

absent intersomitic vessels ( J:132526 )

• typical intersomitic vessels are absent

abnormal placenta vasculature ( J:132526 )

• mutant embryos show normal establishment of allantoic vessels and differentiation of trophoblast cells, but fail to support normal branching or elongation of the vessels and labyrinthine layer in the placenta

abnormal placental labyrinth vasculature morphology ( J:132526 )

• at E9.5, the invasion of allantoic vessels into the labyrinth layer and the number of fetal blood cells are reduced in the mutant placenta

• at E10.5, the invasion process is retracted, and only a few fetal blood cells are found in the chorion

abnormal angiogenesis ( J:132526 )

• at E9.5, blood vessels throughout entire embryo are disorganized

• typical intersomitic vessels are absent, and numerous disorganized vessels are found in the caudal region

abnormal vasculogenesis ( J:132526 )

• vascular formation in head region and heart endocardium remains undeveloped at E8.5 and E9.5

abnormal vitelline vasculature morphology ( J:132526 )

absent vitelline blood vessels ( J:132526 )

• at E9.5, yolk sac fails to develop large vitelline vessels

absent myocardial trabeculae ( J:132526 )

• at E9.5, mutant hearts show a lack of myocardial trabeculation

abnormal aortic sac morphology ( J:132526 )

• at E8.5, the aortic sacs are barely recognizable

abnormal heart development ( J:132526 )

• heart is observed to contain a small tissue clump at E9.5

• at E9.5, hearts show reduced endocardial tissue and abnormal chamber formation and lack of myocardial trabeculation

abnormal heart looping ( J:132526 )

• at E8.5, heart tube has not initiated looping

abnormal endocardium morphology ( J:132526 )

• at E8.5, the endocardium is barely recognizable

• at E9.5, the amount of endocardial tissue is reduced

small heart ( J:132526 )

• at E8.5 and E9.5, mutant embryos display a very small heart

abnormal heart ventricle morphology ( J:132526 )

• at E9.5, mutant embryos show abnormal ventricular chamber formation

abnormal blood circulation ( J:132526 )

• embryos have poor blood circulation; hearts beat, but few blood cells are observed in heart and vessels

• hearts contract irregularly at E9.5

hemorrhage ( J:132526 )

• observed in capital and caudal regions of embryo at E9.5