Phenotypes associated with this allele

• Allele Symbol: Lrat^tm1Bok
• Allele Name: targeted mutation 1, Dean Bok
• Allele ID: MGI:3777016
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lrat^tm1Bok/Lrat^tm1Bok Tg(Tyrp1-cre)1Ipc/?	involves: 129S2/SvPas	MGI:3777086

Genotype
MGI:3777086

cn1

• Allelic Composition: Lrat^tm1Bok/Lrat^tm1Bok; Tg(Tyrp1-cre)1Ipc/?
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

short photoreceptor outer segment ( J:132516 )

• pronounced shortening of the rod outer segment is evident by eight weeks of age and persists into adulthood

abnormal eye electrophysiology ( J:132516 )

• there are severely reduced electroretinogram (ERG) responses to blue-flash stimuli by dark adapted mice

• at the highest stimuli tested, 10-HZ, the relative Fourier amplitude exceeds the signal detected for Lrat^tm1.1Bok mice but is significantly below wild-type mice

homeostasis/metabolism

abnormal vitamin A level ( J:132516 )

• levels of all-trans retinyl esters in the retinal pigment epithelium are 18% of that found in control mice

• levels of all-trans retinyl esters in nonocular tissues are normal

nervous system

short photoreceptor outer segment ( J:132516 )

• pronounced shortening of the rod outer segment is evident by eight weeks of age and persists into adulthood