Phenotypes associated with this allele

• Allele Symbol: Lrat^tm1.1Bok
• Allele Name: targeted mutation 1.1, Dean Bok
• Allele ID: MGI:3777017
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrat^tm1.1Bok/Lrat^tm1.1Bok	involves: 129S2/SvPas	MGI:3777087
cx2	Lrat^tm1.1Bok/Lrat^tm1.1Bok Stra6^tm1Nbg/Stra6^tm1Nbg	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:5532517

Genotype
MGI:3777087

hm1

• Allelic Composition: Lrat^tm1.1Bok/Lrat^tm1.1Bok
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

short photoreceptor outer segment ( J:132516 )

• pronounced shortening of the rod outer segment is evident by six weeks of age and persists into adulthood

abnormal eye electrophysiology ( J:132516 )

• there are no detectable electroretinogram (ERG) responses to blue-flash stimuli by dark adapted mice

homeostasis/metabolism

abnormal vitamin A level ( J:132516 )

• levels of all-trans retinyl esters in the retinal pigment epithelium are 9% of that found in control mice

• levels of all-trans retinyl esters are barely detectable in other tissues including liver and lung

nervous system

short photoreceptor outer segment ( J:132516 )

• pronounced shortening of the rod outer segment is evident by six weeks of age and persists into adulthood

Genotype
MGI:5532517

cx2

• Allelic Composition: Lrat^tm1.1Bok/Lrat^tm1.1Bok; Stra6^tm1Nbg/Stra6^tm1Nbg
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

embryo

embryo phenotype ( J:203449 )

N • mice exposed to excessive retinol exhibit defects as in Lrat^tm1.1Bok homozygotes