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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nr2e1tm1Rev
targeted mutation 1, Ronald M Evans
MGI:3777019
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Nr2e1tm1Rev/Nr2e1tm1Rtyu Not Specified MGI:3777340
cn2
 		Nr2e1tm1Rev/Nr2e1tm1Rev
Tg(CAG-cre/Esr1*)5Amc/? 		involves: C57BL/6 * CBA MGI:3777343
cn3
 		Nr2e1tm1Rev/Nr2e1tm1Rev
Tg(Nes-cre)1Kln/0 		involves: C57BL/6 * SJL MGI:3777346


Genotype
MGI:3777340
ht1
Allelic
Composition		 Nr2e1tm1Rev/Nr2e1tm1Rtyu
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2e1tm1Rev mutation (0 available); any Nr2e1 mutation (32 available)
Nr2e1tm1Rtyu mutation (0 available); any Nr2e1 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:132664 )
• isolated neural stem cells infected with a cre-expressing virus display an 80% reduction in proliferation

cellular
abnormal neuron differentiation ( J:132664 )
• isolated neural stem cells infected with a cre-expressing virus display an 80% reduction in proliferation




Genotype
MGI:3777343
cn2
Allelic
Composition		 Nr2e1tm1Rev/Nr2e1tm1Rev
Tg(CAG-cre/Esr1*)5Amc/?
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2e1tm1Rev mutation (0 available); any Nr2e1 mutation (32 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron differentiation ( J:132664 )
• three weeks of voluntary running results in an increased number of dividing cells in the brain
• reduced pool of neural stem cells

behavior/neurological
behavior/neurological phenotype ( J:132664 )
N
• contextual fear conditioning is normal
• tone-cued memory is normal

cellular
abnormal neuron differentiation ( J:132664 )
• three weeks of voluntary running results in an increased number of dividing cells in the brain
• reduced pool of neural stem cells




Genotype
MGI:3777346
cn3
Allelic
Composition		 Nr2e1tm1Rev/Nr2e1tm1Rev
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2e1tm1Rev mutation (0 available); any Nr2e1 mutation (32 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system

vision/eye
vision/eye phenotype ( J:132664 )
N
• visual function remains at 2-4 months

behavior/neurological
behavior/neurological phenotype ( J:132664 )
N
• contextual fear conditioning is normal
abnormal spatial learning ( J:132664 )
• profoundly impaired in a Morris water maze test
abnormal short-term spatial reference memory ( J:132664 )
• deficient short term memory but normal long term memory in a Morris water maze




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory