Phenotypes associated with this allele

• Allele Symbol: mt-Nd6^m1Dwa
• Allele Name: mutation 1, Douglas C Wallace
• Allele ID: MGI:3777241
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	mt-Co1^m1Jiha mt-Nd6^m1Dwa mt-Nd6^m2Dwa	involves: C3H/An * C57BL/6J * M. m. domesticus	MGI:3810062
ot2	mt-Nd6^m1Dwa	involves: C3H/An * C57BL/6J * M. m. domesticus	MGI:3810061

Genotype
MGI:3810062

cx1

• Allelic Composition: mt-Co1^m1Jiha; mt-Nd6^m1Dwa; mt-Nd6^m2Dwa
• Genetic Background: involves: C3H/An * C57BL/6J * M. m. domesticus

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial ATP synthesis coupled electron transport ( J:132659 )

• mice with 14% mitochondria containing mt-Nd6^m1Dwa and 86% mitochondria containing mt-Nd6^m2Dwa in addition to all mitochondria containing mt-Co1^m1Jiha exhibit reduced complex IV activity compared to in wild-type mice

cardiovascular system

abnormal myocardial fiber physiology ( J:132659 )

• mice with 14% mitochondria containing mt-Nd6^m1Dwa and 86% mitochondria containing mt-Nd6^m2Dwa in addition to all mitochondria containing mt-Co1^m1Jiha exhibit mitochondrial proliferation, mitochondrial autophagy and myofibrillar degeneration unlike in wild-type mice

• however, the percentage of mitochondria with Nd6^m1Dwa did not alter the phenotype

Genotype
MGI:3810061

ot2

• Allelic Composition: mt-Nd6^m1Dwa
• Genetic Background: involves: C3H/An * C57BL/6J * M. m. domesticus

cellular

abnormal mitochondrial ATP synthesis coupled electron transport ( J:132659 )

• activity of complex I and IV are decreased in the brain, heart, liver and skeletal muscles compared to in wild-type mice

• however, this phenotype is not affected by the proportion of mitochondria with the mt-Nd6^m1Dwa allele and was not maintained in subsequent generations due to preferential loss of oocytes containing mt-Nd6