All Phenotypes mt-Nd6<m2Dwa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

mt-Nd6^m2Dwa
mutation 1, Douglas C Wallace
MGI:3777242

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	mt-Co1^m1Jiha mt-Nd6^m1Dwa mt-Nd6^m2Dwa	involves: C3H/An * C57BL/6J * M. m. domesticus	MGI:3810062

Allelic Composition	mt-Co1^m1Jiha mt-Nd6^m1Dwa mt-Nd6^m2Dwa
Genetic Background	involves: C3H/An * C57BL/6J * M. m. domesticus

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
mt-Co1^m1Jiha mutation (0 available); any mt-Co1 mutation (0 available)
mt-Nd6^m1Dwa mutation (0 available); any mt-Nd6 mutation (1 available)
mt-Nd6^m2Dwa mutation (0 available); any mt-Nd6 mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal mitochondrial ATP synthesis coupled electron transport ( J:132659 )

• mice with 14% mitochondria containing mt-Nd6^m1Dwa and 86% mitochondria containing mt-Nd6^m2Dwa in addition to all mitochondria containing mt-Co1^m1Jiha exhibit reduced complex IV activity compared to in wild-type mice

cardiovascular system

abnormal myocardial fiber physiology ( J:132659 )

• mice with 14% mitochondria containing mt-Nd6^m1Dwa and 86% mitochondria containing mt-Nd6^m2Dwa in addition to all mitochondria containing mt-Co1^m1Jiha exhibit mitochondrial proliferation, mitochondrial autophagy and myofibrillar degeneration unlike in wild-type mice

• however, the percentage of mitochondria with Nd6^m1Dwa did not alter the phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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