Phenotypes associated with this allele

• Allele Symbol: Srrt^tm1Bfk
• Allele Name: targeted mutation 1, Ben F Koop
• Allele ID: MGI:3777245
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Srrt^tm1Bfk/Srrt^tm1Bfk	either: (involves: 129S1/Sv * 129S2/SvPasCrl * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Crl:CD-1)	MGI:3777248

Genotype
MGI:3777248

hm1

• Allelic Composition: Srrt^tm1Bfk/Srrt^tm1Bfk
• Genetic Background: either: (involves: 129S1/Sv * 129S2/SvPasCrl * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Crl:CD-1)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:132672 )

• embryos die around E5.5

embryo

increased embryonic tissue cell apoptosis ( J:132672 )

• detected in E3.5 embryos after 24h of culture

• however, the mitotic index is not different from controls

failure of blastocyst to hatch from the zona pellucida ( J:132672 )

• most E3.5 null embryos cultured for 24 fail to hatch from the zona pellucida

embryonic growth arrest ( J:132672 )

• E3.5 embryos in culture are noticeably smaller than controls at 24h and collapse after 48h of culture

• embryos fail to expand even when the zona pellucida is removed

cellular

increased embryonic tissue cell apoptosis ( J:132672 )

• detected in E3.5 embryos after 24h of culture

• however, the mitotic index is not different from controls