All Phenotypes Dab1<tm1Bwh> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dab1^tm1Bwh
targeted mutation 1, Brian W Howell
MGI:3777252

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dab1^tm1Bwh/Dab1^tm1Bwh	involves: 129S4/SvJaeSor * C57BL/6	MGI:3810276
ht2	Dab1^tm1Bwh/Dab1⁺	involves: 129S4/SvJaeSor * C57BL/6	MGI:3810277
cx3	App^tm1Dbo/App^tm1Dbo Dab1^tm1Bwh/Dab1^tm1Bwh	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6	MGI:3810280
cx4	App^tm1Dbo/App⁺ Dab1^tm1Bwh/Dab1^tm1Bwh	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6	MGI:3810281
cx5	Dab1^tm1Bwh/Dab1^tm1Bwh Tg(APPSWE)2576Kha/0	involves: 129S4/SvJaeSor * C57BL/6 * SJL	MGI:3810279

Allelic Composition	Dab1^tm1Bwh/Dab1^tm1Bwh
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm1Bwh mutation (0 available); any Dab1 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal brain morphology ( J:132599 )

• mice exhibit mild ectopias

• CDP+ neurons are more widely dispersed than in wild-type

abnormal cerebellar foliation ( J:132599 )

abnormal cerebellar Purkinje cell layer ( J:132599 )

• Purkinje cells are displaced from the normal monolayer in several folia

ectopic Purkinje cell ( J:132599 )

small cerebellum ( J:132599 )

• the vermis to whole brain ratio is smaller than in wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:132599 )

N	• mice exhibit normal behavior

Allelic Composition	Dab1^tm1Bwh/Dab1⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm1Bwh mutation (0 available); any Dab1 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar foliation ( J:132599 )

• foliation is not as severely affected as in homozygous mice

small cerebellum ( J:132599 )

• cerebellar size is not as reduced as in homozygous mice

Allelic Composition	App^tm1Dbo/App^tm1Dbo Dab1^tm1Bwh/Dab1^tm1Bwh
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm1Dbo mutation (4 available); any App mutation (105 available)
Dab1^tm1Bwh mutation (0 available); any Dab1 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

small cerebellum ( J:132599 )

• the cerebellum volume is not as small as in Dab1^tm1Bwh homozygotes

Allelic Composition	App^tm1Dbo/App⁺ Dab1^tm1Bwh/Dab1^tm1Bwh
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

small cerebellum ( J:132599 )

• the cerebellum volume is not as small as in Dab1^tm1Bwh homozygotes

Allelic Composition	Dab1^tm1Bwh/Dab1^tm1Bwh Tg(APPSWE)2576Kha/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm1Bwh mutation (0 available); any Dab1 mutation (79 available)
Tg(APPSWE)2576Kha mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar foliation ( J:132599 )

• the loss of divisions between some folia is apparent

small cerebellum ( J:132599 )

• the vermis to whole brain ratio is smaller than in Dab1^tm1Bwh homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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