About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Traf3tm1Rbr
targeted mutation 1, Robert Brink
MGI:3777324
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd19tm1(cre)Cgn/Cd19+
Traf3tm1Rbr/Traf3tm1Rbr 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3777344
cn2
 		Cd19tm1(cre)Cgn/Cd19+
Traf2tm1Rbr/Traf2tm1Rbr
Traf3tm1Rbr/Traf3tm1Rbr 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3777347
cn3
 		Tg(Lck-cre)I57Jxm/?
Traf3tm1Rbr/Traf3tm1Rbr 		involves: C57BL/6 * ICR * SJL MGI:3777350
cx4
 		Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Traf3tm1Rbr/Traf3tm1Rbr 		involves: C57BL/6 MGI:5013721


Genotype
MGI:3777344
cn1
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Traf3tm1Rbr/Traf3tm1Rbr
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Traf3tm1Rbr mutation (0 available); any Traf3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased follicular B cell number ( J:132877 )
• there is almost a 2-fold increase in the number of follicular B cells found in the spleen
increased marginal zone B cell number ( J:132877 )
• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes
• surface expression of CD21 on these cells is enhanced
abnormal B cell physiology ( J:132877 )
• 50% of B cells remain viable in unsupplemented culture for up to 10 days compared to no survival of wild-type cells

hematopoietic system
increased follicular B cell number ( J:132877 )
• there is almost a 2-fold increase in the number of follicular B cells found in the spleen
increased marginal zone B cell number ( J:132877 )
• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes
• surface expression of CD21 on these cells is enhanced
abnormal B cell physiology ( J:132877 )
• 50% of B cells remain viable in unsupplemented culture for up to 10 days compared to no survival of wild-type cells




Genotype
MGI:3777347
cn2
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Traf2tm1Rbr/Traf2tm1Rbr
Traf3tm1Rbr/Traf3tm1Rbr
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Traf2tm1Rbr mutation (0 available); any Traf2 mutation (25 available)
Traf3tm1Rbr mutation (0 available); any Traf3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased marginal zone B cell number ( J:132877 )
• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes
• surface expression of CD21 on these cells is enhanced
abnormal B cell physiology ( J:132877 )
• 50% of B cells remain viable in unsupplemented culture for up to 10 days compared to no survival of wild-type cells

hematopoietic system
increased marginal zone B cell number ( J:132877 )
• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes
• surface expression of CD21 on these cells is enhanced
abnormal B cell physiology ( J:132877 )
• 50% of B cells remain viable in unsupplemented culture for up to 10 days compared to no survival of wild-type cells




Genotype
MGI:3777350
cn3
Allelic
Composition		 Tg(Lck-cre)I57Jxm/?
Traf3tm1Rbr/Traf3tm1Rbr
Genetic
Background		 involves: C57BL/6 * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)I57Jxm mutation (1 available)
Traf3tm1Rbr mutation (0 available); any Traf3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:132877 )
• numbers of CD4 T cells in the spleen are slightly reduced
decreased CD8-positive, alpha-beta T cell number ( J:132877 )
• numbers of CD8 T cells in the spleen are slightly reduced
abnormal T cell physiology ( J:132877 )
• extensive activation of the alternative NF-kappaB pathway occurs though no effect on T cell survival is observed

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:132877 )
• numbers of CD4 T cells in the spleen are slightly reduced
decreased CD8-positive, alpha-beta T cell number ( J:132877 )
• numbers of CD8 T cells in the spleen are slightly reduced
abnormal T cell physiology ( J:132877 )
• extensive activation of the alternative NF-kappaB pathway occurs though no effect on T cell survival is observed




Genotype
MGI:5013721
cx4
Allelic
Composition		 Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Traf3tm1Rbr/Traf3tm1Rbr
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)
Traf3tm1Rbr mutation (0 available); any Traf3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:172843 )
N
• mice exhibit normal B cell development in the spleen and lymph node unlike in Tnfrsf13ctm1Mass homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory