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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Traf3tm1Rbr
targeted mutation 1, Robert Brink
MGI:3777324
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd19tm1(cre)Cgn/Cd19+
Traf3tm1Rbr/Traf3tm1Rbr 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3777344
cn2
 		Cd19tm1(cre)Cgn/Cd19+
Traf2tm1Rbr/Traf2tm1Rbr
Traf3tm1Rbr/Traf3tm1Rbr 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:3777347
cn3
 		Tg(Lck-cre)I57Jxm/?
Traf3tm1Rbr/Traf3tm1Rbr 		involves: C57BL/6 * ICR * SJL MGI:3777350
cx4
 		Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Traf3tm1Rbr/Traf3tm1Rbr 		involves: C57BL/6 MGI:5013721


Genotype
MGI:3777344
cn1
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Traf3tm1Rbr/Traf3tm1Rbr
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Traf3tm1Rbr mutation (0 available); any Traf3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased follicular B cell number ( J:132877 )
• there is almost a 2-fold increase in the number of follicular B cells found in the spleen
increased marginal zone B cell number ( J:132877 )
• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes
• surface expression of CD21 on these cells is enhanced
abnormal B cell physiology ( J:132877 )
• 50% of B cells remain viable in unsupplemented culture for up to 10 days compared to no survival of wild-type cells

hematopoietic system
increased follicular B cell number ( J:132877 )
• there is almost a 2-fold increase in the number of follicular B cells found in the spleen
increased marginal zone B cell number ( J:132877 )
• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes
• surface expression of CD21 on these cells is enhanced
abnormal B cell physiology ( J:132877 )
• 50% of B cells remain viable in unsupplemented culture for up to 10 days compared to no survival of wild-type cells




Genotype
MGI:3777347
cn2
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Traf2tm1Rbr/Traf2tm1Rbr
Traf3tm1Rbr/Traf3tm1Rbr
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Traf2tm1Rbr mutation (0 available); any Traf2 mutation (25 available)
Traf3tm1Rbr mutation (0 available); any Traf3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased marginal zone B cell number ( J:132877 )
• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes
• surface expression of CD21 on these cells is enhanced
abnormal B cell physiology ( J:132877 )
• 50% of B cells remain viable in unsupplemented culture for up to 10 days compared to no survival of wild-type cells

hematopoietic system
increased marginal zone B cell number ( J:132877 )
• there are greatly increased numbers of marginal zone B cells in both spleen and lymph nodes
• surface expression of CD21 on these cells is enhanced
abnormal B cell physiology ( J:132877 )
• 50% of B cells remain viable in unsupplemented culture for up to 10 days compared to no survival of wild-type cells




Genotype
MGI:3777350
cn3
Allelic
Composition		 Tg(Lck-cre)I57Jxm/?
Traf3tm1Rbr/Traf3tm1Rbr
Genetic
Background		 involves: C57BL/6 * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)I57Jxm mutation (1 available)
Traf3tm1Rbr mutation (0 available); any Traf3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:132877 )
• numbers of CD4 T cells in the spleen are slightly reduced
decreased CD8-positive, alpha-beta T cell number ( J:132877 )
• numbers of CD8 T cells in the spleen are slightly reduced
abnormal T cell physiology ( J:132877 )
• extensive activation of the alternative NF-kappaB pathway occurs though no effect on T cell survival is observed

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:132877 )
• numbers of CD4 T cells in the spleen are slightly reduced
decreased CD8-positive, alpha-beta T cell number ( J:132877 )
• numbers of CD8 T cells in the spleen are slightly reduced
abnormal T cell physiology ( J:132877 )
• extensive activation of the alternative NF-kappaB pathway occurs though no effect on T cell survival is observed




Genotype
MGI:5013721
cx4
Allelic
Composition		 Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Traf3tm1Rbr/Traf3tm1Rbr
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf13ctm1Mass mutation (1 available); any Tnfrsf13c mutation (15 available)
Traf3tm1Rbr mutation (0 available); any Traf3 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:172843 )
N
• mice exhibit normal B cell development in the spleen and lymph node unlike in Tnfrsf13ctm1Mass homozygotes




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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory