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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rettm1Heno
targeted mutation 1, Hideki Enomoto
MGI:3777553
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rettm1Heno/Rettm1Heno Not Specified MGI:3783341
ht2
Rettm1Heno/Rettm2(RET)Jmi involves: 129X1/SvJ * C57BL/6 MGI:4459065
cn3
Baxtm1Sjk/Baxtm1Sjk
Rettm1Heno/Rettm3.1(Bcl2l1)Heno
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129X1/SvJ * C57BL/6 * CBA MGI:4459062
cn4
Rettm1Heno/Rettm3.1(Bcl2l1)Heno
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129X1/SvJ * C57BL/6 * CBA MGI:4459061
cn5
Rettm1Heno/Rettm2(RET)Heno
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129X1/SvJ * C57BL/6 * CBA MGI:4459060


Genotype
MGI:3783341
hm1
Allelic
Composition
Rettm1Heno/Rettm1Heno
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm1Heno mutation (0 available); any Ret mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• reduced fusimotor innervation of muscle spindles
• muscle spindle innervation normal in Rectus femoris
• peroneal muscles totally lack both motor and sensory innervation in 42% of homozygotes
• 58% with normal peroneal innervation or with innervation absent only in the superficial peroneal muscles
• elevated apoptosis of motor neurons between 13.5 and E15.5

muscle
• reduced in size but with normal motor innervation
• reduced fusimotor innervation of muscle spindles
• muscle spindle innervation normal in Rectus femoris

limbs/digits/tail
• reduced in size but with normal motor innervation




Genotype
MGI:4459065
ht2
Allelic
Composition
Rettm1Heno/Rettm2(RET)Jmi
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm1Heno mutation (0 available); any Ret mutation (54 available)
Rettm2(RET)Jmi mutation (0 available); any Ret mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 23% of mice die between P5 and P31

digestive/alimentary system
• mice exhibit wet stool weight and water stool content compared with control mice
• mice exhibit decreased stool frequency compared with control mice

renal/urinary system
N
• mice exhibit normal kidney development

nervous system
N
• mice exhibit normal motor innervation
• in 8 of 21 mice

embryo
• colonization of the hindgut with enteric neural crest cells is delayed compared to in wild-type mice

growth/size/body

cellular
• colonization of the hindgut with enteric neural crest cells is delayed compared to in wild-type mice




Genotype
MGI:4459062
cn3
Allelic
Composition
Baxtm1Sjk/Baxtm1Sjk
Rettm1Heno/Rettm3.1(Bcl2l1)Heno
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Baxtm1Sjk mutation (1 available); any Bax mutation (24 available)
Rettm1Heno mutation (0 available); any Ret mutation (54 available)
Rettm3.1(Bcl2l1)Heno mutation (0 available); any Ret mutation (54 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• tamoxifen-treated mice exhibit loss of enteric neurons unlike similarly treated control mice (Rettm1Heno/Ret+ Tg(CAG-cre/Esr1*)5Amc mice)




Genotype
MGI:4459061
cn4
Allelic
Composition
Rettm1Heno/Rettm3.1(Bcl2l1)Heno
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm1Heno mutation (0 available); any Ret mutation (54 available)
Rettm3.1(Bcl2l1)Heno mutation (0 available); any Ret mutation (54 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• tamoxifen-treated mice exhibit wet stool weight and water stool content compared with control mice
• tamoxifen-treated mice exhibit decreased stool frequency compared with control mice
• 2 to 5 tamoxifen-treated mice exhibit hard feces that accumulates in the distal colon unlike in control mice

growth/size/body
• in tamoxifen-treated mice

nervous system
• 40% of tamoxifen-treated mice exhibit reduced enteric neurons compared with similarly treated control mice (Rettm1Heno/Ret+ Tg(CAG-cre/Esr1*)5Amc mice)
• tamoxifen-treated mice exhibit fewer NOS-expressing neurons compared to in control mice
• however, 60% of tamoxifen-treated mice exhibit normal enteric nervous system development




Genotype
MGI:4459060
cn5
Allelic
Composition
Rettm1Heno/Rettm2(RET)Heno
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rettm1Heno mutation (0 available); any Ret mutation (54 available)
Rettm2(RET)Heno mutation (0 available); any Ret mutation (54 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• tamoxifen-treated mice exhibit fewer enteric neurons than in similarly controls (Rettm1Heno/Ret+ Tg(CAG-cre/Esr1*)5Amc mice)





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory