All Phenotypes Ret<tm2(RET)Heno> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ret^tm2(RET)Heno
targeted mutation 2, Hideki Enomoto
MGI:3777555

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ret^tm2(RET)Heno/Ret^{tm3.1(Bcl2l1)Heno}	involves: 129/Sv * C57BL/6	MGI:4459058
cn2	Mnx1^tm4(cre)Tmj/Mnx1⁺ Ret^tm2(RET)Heno/Ret^tm2(RET)Heno	involves: 129S1/Sv * C57BL/6 * SJL	MGI:3783346
cn3	Ret^tm2(RET)Heno/Ret^tm2(RET)Jmi Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S/Sv * C57BL/6 * CBA	MGI:4820814
cn4	Ret^tm2(RET)Heno/Ret^tm1Cos Tg(CAG-cre/Esr1*)5Amc/0	involves: 129S/Sv * C57BL/6 * CBA	MGI:4820805
cn5	Ret^tm1Heno/Ret^tm2(RET)Heno Tg(CAG-cre/Esr1*)5Amc/0	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:4459060
cn6	Mnx1^tm4(cre)Tmj/Mnx1⁺ Ret^tm2(RET)Heno/Ret^tm2(RET)Heno	involves: C57BL/6 * SJL	MGI:3783344

Allelic Composition	Ret^tm2(RET)Heno/Ret^{tm3.1(Bcl2l1)Heno}
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm2(RET)Heno mutation (0 available); any Ret mutation (54 available)
Ret^{tm3.1(Bcl2l1)Heno} mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent enteric neurons ( J:159854 )

renal/urinary system

absent kidney ( J:159854 )

Allelic Composition	Mnx1^tm4(cre)Tmj/Mnx1⁺ Ret^tm2(RET)Heno/Ret^tm2(RET)Heno
Genetic Background	involves: 129S1/Sv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mnx1^tm4(cre)Tmj mutation (2 available); any Mnx1 mutation (29 available)
Ret^tm2(RET)Heno mutation (0 available); any Ret mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:132854 )

N	• fusimotor axons are unaffected

Allelic Composition	Ret^tm2(RET)Heno/Ret^tm2(RET)Jmi Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129S/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm2(RET)Heno mutation (0 available); any Ret mutation (54 available)
Ret^tm2(RET)Jmi mutation (0 available); any Ret mutation (54 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

abnormal large intestine morphology ( J:135153 )

• oligoganglionic gut, puncta of nerve fiber and cell body staining are frequently observed in the interganglionic spaces with incomplete penetrance

embryo

decreased neural crest cell number ( J:135153 )

nervous system

decreased neural crest cell number ( J:135153 )

Allelic Composition	Ret^tm2(RET)Heno/Ret^tm1Cos Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129S/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1Cos mutation (2 available); any Ret mutation (54 available)
Ret^tm2(RET)Heno mutation (0 available); any Ret mutation (54 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal enteric ganglia morphology ( J:135153 )

• at E15.5 a nearly complete elimination of the enteric ganglia in the colon when treated with 4-OHT

Allelic Composition	Ret^tm1Heno/Ret^tm2(RET)Heno Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ret^tm1Heno mutation (0 available); any Ret mutation (54 available)
Ret^tm2(RET)Heno mutation (0 available); any Ret mutation (54 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal enteric neuron morphology ( J:159854 )

• tamoxifen-treated mice exhibit fewer enteric neurons than in similarly controls (Ret^tm1Heno/Ret⁺ Tg(CAG-cre/Esr1*)5Amc mice)

Allelic Composition	Mnx1^tm4(cre)Tmj/Mnx1⁺ Ret^tm2(RET)Heno/Ret^tm2(RET)Heno
Genetic Background	involves: C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal motor neuron innervation pattern ( J:132854 )

• absence of fusimotor nerve terminals

decreased motor neuron number ( J:132854 )

• loss of small diameter but not large diameter axons in lumbar ventral roots and in distal medial gastrocnemius nerve

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