Analysis Tools
nervous system
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• mice exhibit increased latency time to tonic-clonic seizure at high doses of PTZ compared to wild-type mice
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• E15.5 embryonic neurons cultured for 5 days and postnatal neurons exhibit an increase in neurite number but decreased mean neurite length compared to wild-type neurons
• however, total neurite length and dendritic field area are normal
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• E15.5 embryonic neurons cultured for 5 days and postnatal neurons exhibit an increase in neurite primary and higher-order processes compared to wild-type neurons
• mice exhibit reduced dendritic spine density and mature morphology in superficial cortical layers compared to in wild-type mice
• excitatory synapses on dendritic spines (as determined by the ratio of PSD-95 puncta to MAP-2 staining) in the cortical layers II/III are reduced compared to in wild-type mice
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• while inhibitory signaling is normal, mice exhibit impaired excitatory postsynaptic potential and current summation with increasing stimulus intensities
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• mice fail to exhibit summation of excitatory postsynaptic currents when exposed to increasing stimulus intensities unlike wild-type mice
• however, failure rates in response to minimal stimulation are normal
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• mice exhibit reduced excitatory postsynaptic potential (EPSP) compared to wild-type mice
• mice fail to exhibit summation of EPSP when exposed to increasing stimulus intensities unlike wild-type mice
• however, action potential thresholds are normal
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behavior/neurological
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• mice exhibit increased latency time to tonic-clonic seizure at high doses of PTZ compared to wild-type mice
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• mice fail to exhibit a preference for the target quadrant after the training period in a Morris water maze unlike wild-type mice
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• mice exhibit reduced baseline activity during the tail suspension test and shorter latency to fall from an accelerating rota-rod compared to wild-type mice
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• in locomotor tests mice cover less distance and are less prone to rearing behavior than in wild-type mice
• however, exploratory behavior is normal
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• when tested in a Morris water maze on day 15 mice exhibit reduced swim speed and distance
• however, mice swim normally at day 8 in a Morris water maze
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• in locomotor tests mice cover less distance and are less prone to rearing behavior than in wild-type mice
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• mice are hypoactive once habituated compared to wild-type mice
• however, mice exhibit normal exploratory behavior in a new environment
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