Phenotypes associated with this allele

• Allele Symbol: Rap1b^tm1Morz
• Allele Name: targeted mutation 1, Alexei Morozov
• Allele ID: MGI:3777593
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rap1a^tm1Morz/Rap1a^tm1Morz Rap1b^tm1Morz/Rap1b^tm1Morz Tg(Camk2a-cre)1Szi/?	involves: 129S/SvEv * C57BL/6J * CBA	MGI:3777607

Genotype
MGI:3777607

cn1

• Allelic Composition: Rap1a^tm1Morz/Rap1a^tm1Morz; Rap1b^tm1Morz/Rap1b^tm1Morz; Tg(Camk2a-cre)1Szi/?
• Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system physiology ( J:132855 )

• protein levels of Rap1 are reduced by 89.4% in the cortex and 38.7% in the thalamus

abnormal excitatory postsynaptic potential ( J:132855 )

• synaptic efficacy in cortical but not thalamic input to the lateral amygdale is 2.5-fold higher than in wild-type mice

• current-voltage relationships for AMPAR and NMDAR currents are similar to wild-type mice

reduced long-term potentiation ( J:132855 )

• in the cortico-amygdala pathway, spike-timing-dependent LTP was substantially reduced with only 2 of 7 cells showing a LTP response compared to 8 of 11 cells from wild-type

abnormal synaptic glutamate release ( J:132855 )

• EPSC evoked by minimal stimulation of cortical inputs into the lateral amygdale reveals increased release of glutamate

decreased paired-pulse facilitation ( J:132855 )

• mice do not demonstrate PPF in cortical inputs to the lateral amygdale before or after long-term potentiation

behavior/neurological

abnormal cued conditioning behavior ( J:132855 )

• mice have reduced fear learning as measured by freezing to a conditioned stimulus both 3 hours and 48 hours after training with a moderately adversive unconditioned stimulus

• there is no difference in fear learning compared to wild-type mice when a more severe unconditioned stimulus is used in training