Analysis Tools
mortality/aging
|
• mice homozygous for this mutation die at about 3 weeks of age
|
pigmentation
|
• the ears of homozygous mutant mice are dark gray
|
|
• the fur of homozygous mutant mice is dark gray
|
|
• homozygous mutant mice have dark gray feet
|
|
• homozygous mutants have dark gray tails
|
limbs/digits/tail
|
• homozygous mutants have dark gray tails
|
craniofacial
|
• the ears of homozygous mutant mice are dark gray
|
hearing/vestibular/ear
|
• the ears of homozygous mutant mice are dark gray
|
behavior/neurological
|
• when placed in a supine position, homozygous mutants have difficulty righting themselves
|
opisthotonus
(
J:133119
)
|
• when placed in a supine position, homozygous mutant mice exhibit convulsive arching of the head and neck (opisthotonus)
|
|
• when prone, mutant mice extend all four feet caudally
• all the digits of homozygous mutants are kept splayed
|
|
• when placed in a supine position, homozygous mutant mice exhibit abrupt movements of the feet (simultaneous with opisthotounus)
|
muscle
opisthotonus
(
J:133119
)
|
• when placed in a supine position, homozygous mutant mice exhibit convulsive arching of the head and neck (opisthotonus)
|
|
• when placed in a supine position, homozygous mutant mice exhibit abrupt movements of the feet (simultaneous with opisthotounus)
|
nervous system
| N |
• histological analysis of brains of mutant mice has revealed no consistent abnormalities
|
|
• when placed in a supine position, homozygous mutant mice exhibit abrupt movements of the feet (simultaneous with opisthotounus)
|
integument
|
• the ears of homozygous mutant mice are dark gray
|
|
• the fur of homozygous mutant mice is dark gray
|
|
• homozygous mutant mice have dark gray feet
|
|
• homozygous mutants have dark gray tails
|
growth/size/body
|
• the ears of homozygous mutant mice are dark gray
|
