Analysis Tools
mortality/aging
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• mice homozygous for this mutation die at about 3 weeks of age
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pigmentation
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• the ears of homozygous mutant mice are dark gray
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• the fur of homozygous mutant mice is dark gray
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• homozygous mutant mice have dark gray feet
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• homozygous mutant mice have dark gray tails
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limbs/digits/tail
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• homozygous mutant mice have dark gray tails
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craniofacial
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• the ears of homozygous mutant mice are dark gray
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hearing/vestibular/ear
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• the ears of homozygous mutant mice are dark gray
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behavior/neurological
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• when placed in a supine position, homozygous mutants have difficulty righting themselves
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opisthotonus
(
J:133120
)
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• when placed in a supine position, homozygous mutant mice exhibit convulsive arching of the head and neck (opisthotonus)
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• when prone, mutant mice extend all four feet caudally
• all the digits of homozygous mutants are kept splayed
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• when placed in a supine position, homozygous mutant mice exhibit abrupt movements of the feet (simultaneous with opisthotounus)
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muscle
opisthotonus
(
J:133120
)
|
• when placed in a supine position, homozygous mutant mice exhibit convulsive arching of the head and neck (opisthotonus)
|
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• when placed in a supine position, homozygous mutant mice exhibit abrupt movements of the feet (simultaneous with opisthotounus)
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nervous system
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• when placed in a supine position, homozygous mutant mice exhibit abrupt movements of the feet (simultaneous with opisthotounus)
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integument
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• the ears of homozygous mutant mice are dark gray
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• the fur of homozygous mutant mice is dark gray
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• homozygous mutant mice have dark gray feet
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• homozygous mutant mice have dark gray tails
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growth/size/body
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• the ears of homozygous mutant mice are dark gray
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