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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Camk2a-cre)1Shn
transgene insertion 1, Jie Shen
MGI:3777953
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ncstntm1.1Sud/Ncstntm1.1Sud
Tg(Camk2a-cre)1Shn/0 		B6.Cg-Ncstntm1.1Sud Tg(Camk2a-cre)1Shn MGI:3848927
cn2
 		Psen1tm2Shn/Psen1tm4.1Shn
Psen2tm1Haa/Psen2tm1Haa
Tg(Camk2a-cre)1Shn/0 		involves: 129 * 129S4/SvJae * C57BL/6 * C57BL/6J * CBA MGI:5754385
cn3
 		Psen1tm2Shn/Psen1tm2Shn
Tg(Camk2a-cre)1Shn/0 		involves: 129S4/SvJae * C57BL/6J * CBA MGI:3777984
cn4
 		Psen1tm2Shn/Psen1tm2.1Shn
Tg(Camk2a-cre)1Shn/0 		involves: 129S4/SvJae * C57BL/6J * CBA MGI:3777985


Genotype
MGI:3848927
cn1
Allelic
Composition		 Ncstntm1.1Sud/Ncstntm1.1Sud
Tg(Camk2a-cre)1Shn/0
Genetic
Background		 B6.Cg-Ncstntm1.1Sud Tg(Camk2a-cre)1Shn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncstntm1.1Sud mutation (0 available); any Ncstn mutation (34 available)
Tg(Camk2a-cre)1Shn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:149506 )
N
• brain morphology is normal at 2 months
increased neuron apoptosis ( J:149506 )
• progressive as early as 2 months
loss of cortex neurons ( J:149506 )
• at 6 and 9 months, mice exhibit cortical atrophy with loss of cortical neurons unlike wild-type mice
thin cerebral cortex ( J:149506 )
• at 6 and 9 months, neocortical volume is decreased compared to in wild-type mice
gliosis ( J:149506 )
• progressive as early as 2 months
abnormal dendrite morphology ( J:149506 )
• mice exhibit age-dependent dendrite loss unlike wild-type mice

behavior/neurological
behavior/neurological phenotype ( J:149506 )
N
• mice exhibit normal swimming abilities, activity levels, and coordination
impaired contextual conditioning behavior ( J:149506 )
• long term-term associative fear memory in a contextual conditioning assay is impaired in an age-dependent manner compared to in wild-type mice
abnormal spatial learning ( J:149506 )
• in a Morris water maze, mice exhibit age-dependent impaired spatial learning compared with wild-type mice
impaired spatial working memory ( J:149506 )
• in a Morris water maze with hidden platform, mice exhibit age-dependent impaired spatial memory compared with wild-type mice

cellular
increased neuron apoptosis ( J:149506 )
• progressive as early as 2 months




Genotype
MGI:5754385
cn2
Allelic
Composition		 Psen1tm2Shn/Psen1tm4.1Shn
Psen2tm1Haa/Psen2tm1Haa
Tg(Camk2a-cre)1Shn/0
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm2Shn mutation (1 available); any Psen1 mutation (48 available)
Psen1tm4.1Shn mutation (0 available); any Psen1 mutation (48 available)
Psen2tm1Haa mutation (0 available); any Psen2 mutation (32 available)
Tg(Camk2a-cre)1Shn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
microgliosis ( J:219929 )
• in the neocortex and hippocampus
abnormal cerebral cortex morphology ( J:219929 )
• 31.5% reduction in cortical volume at 18 months of age
abnormal neocortex morphology ( J:219929 )
• increase in apoptosis in the neocortex
astrocytosis ( J:219929 )
• in the cortex
decreased neuron number ( J:219929 )
• 22.1% reduction in neuron number in the cerebral cortex at 18 months of age
neurodegeneration ( J:219929 )
• mice exhibit age-dependent neurodegeneration throughout the cerebral cortex

hematopoietic system
microgliosis ( J:219929 )
• in the neocortex and hippocampus

immune system
microgliosis ( J:219929 )
• in the neocortex and hippocampus

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alzheimer's disease DOID:10652 J:219929




Genotype
MGI:3777984
cn3
Allelic
Composition		 Psen1tm2Shn/Psen1tm2Shn
Tg(Camk2a-cre)1Shn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm2Shn mutation (1 available); any Psen1 mutation (48 available)
Tg(Camk2a-cre)1Shn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spatial learning ( J:71606 )
• mice show mild defect in spatial learning
abnormal long-term spatial reference memory ( J:71606 )
• mice have mild but significant impairment in spatial learning and memory
• in the Morris water maze paradigm, mutants and wild-type mice show improvements in performance for the initial 7 days of training, but for the last 3-5 days, mutant performance plateaus while control mice continue to improve in finding the hidden platform
• in probe trials, mutants diplay fewer crossings of the target quadrant after 10 days of training compared to wild-type mice
• similar results are obtained when platform position is changed and test is repeated

nervous system
nervous system phenotype ( J:71606 )
N
• examination of brains at P18, 20, 22, and 3 months shows no gross abnormalities
• no increase in apoptosis is observed at any ages examined
• normal synaptic transmission and plasticity in the Schaeffer collateral pathway are observed
amyloid beta deposits ( J:71606 )
• Abeta40 levels are reduced in cortex relative to control brains, while Abeta42 levels are elevated

homeostasis/metabolism
amyloid beta deposits ( J:71606 )
• Abeta40 levels are reduced in cortex relative to control brains, while Abeta42 levels are elevated




Genotype
MGI:3777985
cn4
Allelic
Composition		 Psen1tm2Shn/Psen1tm2.1Shn
Tg(Camk2a-cre)1Shn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm2.1Shn mutation (0 available); any Psen1 mutation (48 available)
Psen1tm2Shn mutation (1 available); any Psen1 mutation (48 available)
Tg(Camk2a-cre)1Shn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal spatial learning ( J:71606 )
• mice show mild defect in spatial learning
abnormal long-term spatial reference memory ( J:71606 )
• mice have mild but significant impairment in spatial learning and memory
• in the Morris water maze paradigm, mutants and wild-type mice show improvements in performance for the initial 7 days of training, but for the last 3-5 days, mutant performance plateaus while control mice continue to improve in finding the hidden platform
• in probe trials, mutants diplay fewer crossings of the target quadrant after 10 days of training compared to wild-type mice
• similar results are obtained when platform position is changed and test is repeated

nervous system
nervous system phenotype ( J:71606 )
N
• examination of brains at P18, 20, 22, and 3 months shows no gross abnormalities
• no increase in apoptosis is observed at any ages examined
• normal synaptic transmission and plasticity in the Schaeffer collateral pathway are observed
amyloid beta deposits ( J:71606 )
• Abeta40 levels are reduced in cortex relative to control brains, while Abeta42 levels are elevated

homeostasis/metabolism
amyloid beta deposits ( J:71606 )
• Abeta40 levels are reduced in cortex relative to control brains, while Abeta42 levels are elevated




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory