Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Thy1-MAPT*P301S)2541Godt transgene insertion 2541, Michel Goedert MGI:3778191 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 12 months, mice exhibit a greater than 50-fold increase in Gallyas+ neurofibrillary pathology compared with Tg(Thy1-MAPT*P301S)2541Godt mice
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• at 12 months, mice exhibit an 18-fold increase in neocortex Tau inclusions compared with Tg(Thy1-MAPT*P301S)2541Godt mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at 12 months, mice exhibit a 3- to 4-fold increase in Tau lesions compared with Tg(Thy1-MAPT*P301S)2541Godt mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are unable to extend their hindlimbs when lifted by the tail
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• mice develop severe paraparesis by 5-6 months of age
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• atrophic, angulated muscle fibers are frequently seen in hindlimb skeletal muscle, indicative of denervation atrophy
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• mice develop general muscle weakness at 5-6 months of age
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• large numbers of abnormal tau filaments are seen in the cytoplasm and processes of nerve cells from 5-6 month old mice
• majority of filaments resemble half-twisted ribbons seen in FTDP-17, while a minority resemble paired helical filaments of Alzheimers disease
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• reactive astrocytosis in the motor neurons of the anterior horn of the spinal cord
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• reduction in the number of motor neurons in the ventral gray matter of 6 month old mutants
• 49% reduction in the number of motor neurons in the anterior horn of the spinal cord
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• neuronal cell bodies are often swollen or severely atrophic
• occasionally pyknotic neurons are surrounded by glial cells, suggesting neuronophagia
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| frontotemporal dementia | DOID:9255 |
OMIM:600274 |
J:108870 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/05/2024 MGI 6.24 |
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