Phenotypes associated with this allele

• Allele Symbol: Tg(DRD1-ctxA)7Burt
• Allele Name: transgene insertion 7, Frank H Burton
• Allele ID: MGI:3778286
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(DRD1-ctxA)7Burt/0	C.Cg-Tg(DRD1-ctxA)7Burt	MGI:3778393
tg2	Tg(DRD1-ctxA)7Burt/0	either: C.Cg-Tg(DRD1-ctxA)7Burt or (involves: BALB/c * C57BL/6)	MGI:3778380

Genotype
MGI:3778393

tg1

• Allelic Composition: Tg(DRD1-ctxA)7Burt/0
• Genetic Background: C.Cg-Tg(DRD1-ctxA)7Burt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:133402 )

N • mice display normal olfactory discrimination

abnormal behavior ( J:64883 , J:133401 )

• low-doses of MK-801 (non-competitive NMDA receptor antagonist) aggravate the repetitive climbing and leaping behavior of transgenic mice (J:64883)

• mice engage in obsessive-compulsive disorder-like behavior such as prolonged episodes of essentially normal behaviors; total behavior repertoire and average number of behaviors is similar to wild-type (J:133401)

increased anxiety-related response ( J:133401 )

• in light-dark assay, mice display longer latency to first transit from dark chamber and show tendency to spend less time in lighted (reduced transits) areas than controls

increased thigmotaxis ( J:133401 )

• mice exhibit increased thigmotaxis in an open-field assay, compared to non-transgenic littermates

abnormal involuntary movement ( J:133268 )

• repetitive twitches (tics) occur at 5-fold higher frequency compared to controls which show twitches infrequently with tics a greater increased frequency observed in females

• tic complexity is increased compared to controls with a higher percentage of non-shaking tics observed; this is statistically significant in females and approaches significance in males relative to control

• occurrence of tic flurries is highly increased in males compared to controls and to a lesser but significant extent in females

• tics are significantly increased in juvenile transgenic animals and adult animals compared to controls

• clonidine (non-cataleptic drug) treatment reduces incidence of tics without affecting locomotor behavior similar to its effects in humans with Tourette's + obsessive compulsive disorder

increased stereotypic behavior ( J:64883 , J:133401 , J:133402 )

• at high doses of MK-801, transgenic mice engage in more severe stereotypic/seizure behavior ( such as 'popping') (J:64883)

• treatment with an AMPA receptor antagonist attenuates MK-801-induced stereotypic behaviors, but does not alter transgene-induced (repetitive climbing/leaping) behavior (J:64883)

• upon injection with yohimbine, transgenic animals display a significant increase abnormal repetitive leaping/climbing behavior compared to saline-injected control transgenics, but duration of perseverative (prolonged) episodes is not exacerbated (J:133401)

• mice display compulsion-like behaviors including prolonged behavior such as eating and repetitive behavior like leaping (J:133402)

• presence of a novel odor or a familiar odor in the cage does not potentiate abnormal repetitive leaping-climbing behavior compared to controls (J:133402)

• presence of an anxiogenic odor in the cage increases incidence of leaping-climbing 2-fold relative to controls; anxiogenic odor potentiates compulsion-like behavior (J:133402)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Gilles de la Tourette syndrome		DOID:11119	OMIM:137580	J:133268 , J:133402

Genotype
MGI:3778380

tg2

• Allelic Composition: Tg(DRD1-ctxA)7Burt/0
• Genetic Background: either: C.Cg-Tg(DRD1-ctxA)7Burt or (involves: BALB/c * C57BL/6)

behavior/neurological

decreased aggression towards mice ( J:55492 )

• transgenic mice attack intruder mice less frequently and show longer latency to attack than control littermates in a resident-intruder aggression assay

increased locomotor activity ( J:55492 )

• transgenic animals exhibit varying degrees of hyperlocomotion

increased stereotypic behavior ( J:55492 )

• mice exhibit stereotypic behaviors including increased repetitive locomotion, repetitive wall leaping, and gnawing whereas leaping is not observed in nontransgenic littermates

• transgenic mice exhibit perseverative episodes of all normal behaviors, consisting of long-duration episodes of stationary single-state behaviors (eating, drinking, grooming, etc) and long-duration episodes of reiterated locomotor-dependent (two state) behavior (ie. locomote- forage- locomote- explore); behavioral duration is about 3-fold greater than in control animals; stationary behavior episodes are also 3-fold greater

• both males and females display nonaggressive, repetitive biting of littermates; such episodes occur during episodes of social grooming, not during aggressive displays or fighting and begins when mice are less than 3 weeks of age

nervous system

nervous system phenotype ( J:55492 )

N • brain is anatomically normal, with no discernible change in CNS morphology or neuron number

abnormal somatosensory cortex morphology ( J:55492 )

• cAMP content is elevated 38% relative to controls

abnormal olfactory cortex morphology ( J:55492 )

• cAMP content is elevated 38% relative to controls