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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ern1tm1Dron
targeted mutation 1, David Ron
MGI:3778372
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ern1tm1Dron/Ern1tm1Dron involves: 129S6/SvEvTac MGI:3809784
ht2
 		Ern1tm1Dron/Ern1+ 129S.129S6-Ern1tm1Dron MGI:3809789


Genotype
MGI:3809784
hm1
Allelic
Composition		 Ern1tm1Dron/Ern1tm1Dron
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ern1tm1Dron mutation (1 available); any Ern1 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:132966 )
• mice die between E9.5 and E11.5 of unknown cause




Genotype
MGI:3809789
ht2
Allelic
Composition		 Ern1tm1Dron/Ern1+
Genetic
Background		 129S.129S6-Ern1tm1Dron
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ern1tm1Dron mutation (1 available); any Ern1 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal glucose homeostasis ( J:132805 )
• mice exhibit reduced glucotoxic effects of chronic high glucose compared to wild-type mice
abnormal response/metabolism to endogenous compounds ( J:132805 )
• mice exhibit reduced glucotoxic effects of chronic high glucose compared to wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory