Phenotypes associated with this allele

• Allele Symbol: Prkd1^tm1Eno
• Allele Name: targeted mutation 1, Eric N Olson
• Allele ID: MGI:3778381
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Prkd1^tm1Eno/Prkd1^tm1Eno Tg(Myh6-cre)2182Mds/?	involves: 129S/SvEv * C57BL/6 * FVB/N	MGI:3778390

Genotype
MGI:3778390

cn1

• Allelic Composition: Prkd1^tm1Eno/Prkd1^tm1Eno; Tg(Myh6-cre)2182Mds/?
• Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart weight ( J:132803 )

• three weeks after surgical thoracic aortic constriction (TAC), mice have 50% less weight gain in the heart compared to wild-type mice

• mice only increase heart weight by 11% compared to 16% for wild-type mice after two weeks treatment with angiotensin II

• mice only increase heart weight by 21% compared to 37% increase in wild-type mice one week after isoproterenol treatment

abnormal heart left ventricle morphology ( J:132803 )

• three weeks after TAC surgery, mice have minimal increase in left ventricle wall thickness unlike wild-type mice that have pronounced thickening of the left ventricle wall in response to TAC

• mice are resistant to dilation of left ventricle that occurs three weeks after TAC surgery in wild-type mice

cardiac fibrosis ( J:132803 )

• mice have much less fibrosis of the heart three weeks after TAC surgery compared to wild-type mice

• less fibrosis also occurs compared to wild-type mice in response to angiotensin II treatment

increased cardiac muscle contractility ( J:132803 )

• mice do not display a decrease in fractional shortening three weeks after TAC surgery while wild-type mice have significant decreases

abnormal heart rate ( J:132803 )

• mice are resistant to reductions in heart rate that occur three weeks after thoracic aortic constriction (TAC) surgery

muscle

increased cardiac muscle contractility ( J:132803 )

• mice do not display a decrease in fractional shortening three weeks after TAC surgery while wild-type mice have significant decreases

growth/size/body

increased heart weight ( J:132803 )

• three weeks after surgical thoracic aortic constriction (TAC), mice have 50% less weight gain in the heart compared to wild-type mice

• mice only increase heart weight by 11% compared to 16% for wild-type mice after two weeks treatment with angiotensin II

• mice only increase heart weight by 21% compared to 37% increase in wild-type mice one week after isoproterenol treatment