Phenotypes associated with this allele

• Allele Symbol: Bmf^tm1.1Ast
• Allele Name: targeted mutation 1.1, Andreas Strasser
• Allele ID: MGI:3778610
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmf^tm1.1Ast/Bmf^tm1.1Ast	B6.Cg-Bmf^tm1.1Anst	MGI:3784612
hm2	Bmf^tm1.1Ast/Bmf^tm1.1Ast	involves: C57BL/6	MGI:5796284

Genotype
MGI:3784612

hm1

• Allelic Composition: Bmf^tm1.1Ast/Bmf^tm1.1Ast
• Genetic Background: B6.Cg-Bmf^tm1.1Anst

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased B cell apoptosis ( J:133084 )

• highly resistant to apoptosis caused by dexamethasone

decreased T cell apoptosis ( J:133084 )

• double positive T cells with increased resistance to the apoptotic effects of dexamethasone

• thymocytes and double positive T cells resistant to the apoptotic effects of suberoylanilide hydroxamic acid

increased T cell derived lymphoma incidence ( J:133084 )

• increased susceptibility to gamma irradiation induced thymic lymphomas made up of double positive or CD8 single positive cells

abnormal spleen morphology ( J:133084 )

enlarged spleen ( J:133084 )

• significantly enlarged at 12 months

spleen hyperplasia ( J:133084 )

• increased by more than 50%

increased immunoglobulin level ( J:133084 )

• total serum levels elevated at 8-10 weeks but not at 1 year of age

abnormal immune system cell morphology ( J:133084 )

abnormal B cell morphology ( J:133084 )

increased immature B cell number ( J:133084 )

increased transitional stage B cell number ( J:133084 )

• both T1 and T2 transitional B cells are elevated

• increased T1 transitional B cells in inguinal lymph nodes

increased mature B cell number ( J:133084 )

• mature B cell numbers are elevated

• increased numbers in inguinal lymph nodes

• increased numbers in peripheral blood

increased follicular B cell number ( J:133084 )

• elevated while marginal B cell numbers are normal

increased pre-B cell number ( J:133084 )

• significantly elevated numbers in bone marrow while pro-B cell numbers are normal

neoplasm

neoplasm ( J:133084 )

N • no B cell neoplasia through 18 months of age

increased T cell derived lymphoma incidence ( J:133084 )

• increased susceptibility to gamma irradiation induced thymic lymphomas made up of double positive or CD8 single positive cells

hematopoietic system

decreased B cell apoptosis ( J:133084 )

• highly resistant to apoptosis caused by dexamethasone

decreased T cell apoptosis ( J:133084 )

• double positive T cells with increased resistance to the apoptotic effects of dexamethasone

• thymocytes and double positive T cells resistant to the apoptotic effects of suberoylanilide hydroxamic acid

increased T cell derived lymphoma incidence ( J:133084 )

• increased susceptibility to gamma irradiation induced thymic lymphomas made up of double positive or CD8 single positive cells

abnormal B cell morphology ( J:133084 )

increased immature B cell number ( J:133084 )

increased transitional stage B cell number ( J:133084 )

• both T1 and T2 transitional B cells are elevated

• increased T1 transitional B cells in inguinal lymph nodes

increased mature B cell number ( J:133084 )

• mature B cell numbers are elevated

• increased numbers in inguinal lymph nodes

• increased numbers in peripheral blood

increased follicular B cell number ( J:133084 )

• elevated while marginal B cell numbers are normal

increased pre-B cell number ( J:133084 )

• significantly elevated numbers in bone marrow while pro-B cell numbers are normal

abnormal spleen morphology ( J:133084 )

enlarged spleen ( J:133084 )

• significantly enlarged at 12 months

spleen hyperplasia ( J:133084 )

• increased by more than 50%

increased immunoglobulin level ( J:133084 )

• total serum levels elevated at 8-10 weeks but not at 1 year of age

cellular

decreased B cell apoptosis ( J:133084 )

• highly resistant to apoptosis caused by dexamethasone

decreased T cell apoptosis ( J:133084 )

• double positive T cells with increased resistance to the apoptotic effects of dexamethasone

• thymocytes and double positive T cells resistant to the apoptotic effects of suberoylanilide hydroxamic acid

growth/size/body

enlarged spleen ( J:133084 )

• significantly enlarged at 12 months

spleen hyperplasia ( J:133084 )

• increased by more than 50%

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:133084 )

• increased susceptibility to gamma irradiation induced thymic lymphomas made up of double positive or CD8 single positive cells

Genotype
MGI:5796284

hm2

• Allelic Composition: Bmf^tm1.1Ast/Bmf^tm1.1Ast
• Genetic Background: involves: C57BL/6

endocrine/exocrine glands

abnormal involution of the mammary gland ( J:235354 )

♀ • delay in postlactational remodeling of the mammary gland

integument

abnormal involution of the mammary gland ( J:235354 )

♀ • delay in postlactational remodeling of the mammary gland