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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Socs1tm1Ayos
targeted mutation 1, Akihiko Yoshimura
MGI:3778686
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Socs1tm1Ayos/Socs1tm1Ayos involves: 129S4/SvJae * C57BL/6 MGI:3783709
cn2
 		Socs1tm1Ayos/Socs1tm1Ayos
Foxp3tm4(YFP/icre)Ayr/Foxp3+ 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:4887825
cn3
 		Socs1tm1Ayos/Socs1tm1Ayos
Tg(Lck-cre)1Jtak/0 		involves: 129S4/SvJae * C57BL/6 MGI:3783712
cn4
 		Socs1tm1Ayos/Socs1tm1Ayos
Tg(Tek-cre)1Ywa/0 		involves: 129S4/SvJae * C57BL/6 * SJL MGI:3783710


Genotype
MGI:3783709
hm1
Allelic
Composition		 Socs1tm1Ayos/Socs1tm1Ayos
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1tm1Ayos mutation (1 available); any Socs1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:132905 )
• most mice appear normal until the age of 4 months




Genotype
MGI:4887825
cn2
Allelic
Composition		 Socs1tm1Ayos/Socs1tm1Ayos
Foxp3tm4(YFP/icre)Ayr/Foxp3+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (58 available)
Socs1tm1Ayos mutation (1 available); any Socs1 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
blepharitis ( J:167922 )
• by 6 weeks of age
conjunctivitis ( J:167922 )
• by 6 weeks of age
dermatitis ( J:167922 )
• by 6 weeks of age

integument
dermatitis ( J:167922 )
• by 6 weeks of age

vision/eye
blepharitis ( J:167922 )
• by 6 weeks of age
conjunctivitis ( J:167922 )
• by 6 weeks of age

hematopoietic system




Genotype
MGI:3783712
cn3
Allelic
Composition		 Socs1tm1Ayos/Socs1tm1Ayos
Tg(Lck-cre)1Jtak/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1tm1Ayos mutation (1 available); any Socs1 mutation (30 available)
Tg(Lck-cre)1Jtak mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal CD4-positive T cell differentiation ( J:132905 )
• IL-17 producing CD4+ T cells differentiated in vitro and induced with IL-6 and TGF-beta with the anti-TCR antibody results in stronger induction of IFN-gamma producing cells and a marked reduction of IL-17 producing cells in contrast to similarly treated wild-type cells
• CD4+ T cells preferentially differentiate into Th1 cells and not Th17 unlike wild-type cells
abnormal CD4-positive, alpha-beta T cell physiology ( J:132905 )
• CD4+ T cells are resistant to the suppressive effects of TGF-beta on IGN-gamma production unlike wild-type cells
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:132905 )
• mice are less susceptible to experimental autoimmune encephalomyelitis (EAE) and produce less IL-17 following EAE compared to wild-type mice

hematopoietic system
abnormal CD4-positive T cell differentiation ( J:132905 )
• IL-17 producing CD4+ T cells differentiated in vitro and induced with IL-6 and TGF-beta with the anti-TCR antibody results in stronger induction of IFN-gamma producing cells and a marked reduction of IL-17 producing cells in contrast to similarly treated wild-type cells
• CD4+ T cells preferentially differentiate into Th1 cells and not Th17 unlike wild-type cells
abnormal CD4-positive, alpha-beta T cell physiology ( J:132905 )
• CD4+ T cells are resistant to the suppressive effects of TGF-beta on IGN-gamma production unlike wild-type cells




Genotype
MGI:3783710
cn4
Allelic
Composition		 Socs1tm1Ayos/Socs1tm1Ayos
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs1tm1Ayos mutation (1 available); any Socs1 mutation (30 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:132905 )
• mice die by 50 days of age of diseases similar to those observed in other Socs1 null mice

immune system
decreased CD4-positive, alpha-beta T cell number ( J:132905 )
• mice exhibit decreased numbers of CD4+ T cells in the thymus and spleen compared to in wild-type mice
increased CD8-positive, alpha-beta T cell number ( J:132905 )
• mice exhibit increased numbers of CD8+ T cells compared to in wild-type mice

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:132905 )
• mice exhibit decreased numbers of CD4+ T cells in the thymus and spleen compared to in wild-type mice
increased CD8-positive, alpha-beta T cell number ( J:132905 )
• mice exhibit increased numbers of CD8+ T cells compared to in wild-type mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory