Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ightm1Jiac targeted mutation 1, John Iacomini MGI:3778805 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the frequency of B220+ B cells in the periphery is 18.7% compared to 24.7% in mice with just one Igh knock-in allele
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• the frequency of B220+ B cells in the periphery is 18.7% compared to 24.7% in mice with just one Igh knock-in allele
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the frequency of B220+ B cells in the periphery is 10.1% compared to 24.7% in mice with just one Igk knock-in allele
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• the frequency of B220+ B cells in the periphery is 10.1% compared to 24.7% in mice with just one Igk knock-in allele
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• anti-alphaGal IgM is detectable in the sera of mice
• the frequency of B cells expressing anti-alphaGal IgM in the spleen is higher than controls
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• the frequency of B220+ B cells in the periphery is 6.6% compared to 24.7% in mice with just one knock-in allele for Igk and Igh
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• the anti-alphaGal IgM produced by B cells has a lower affinity for antigen than immunoglobulins produced in mice with with no endogenous expression of alphaGal
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• anti-alphaGal IgM is detectable in the sera of mice
• the frequency of B cells expressing anti-alphaGal IgM in the spleen is higher than controls
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• the frequency of B220+ B cells in the periphery is 6.6% compared to 24.7% in mice with just one knock-in allele for Igk and Igh
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• the anti-alphaGal IgM produced by B cells has a lower affinity for antigen than immunoglobulins produced in mice with with no endogenous expression of alphaGal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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