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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igktm1Jiac
targeted mutation 1, John Iacomini
MGI:3778809
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Ggta1tm1Jbl/Ggta1+
Ightm1Jiac/Ightm1Jiac
Igktm1Jiac/Igk+ 		involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 MGI:3779041
cx2
 		Ggta1tm1Jbl/Ggta1+
Ightm1Jiac/Igh+
Igktm1Jiac/Igktm1Jiac 		involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 MGI:3779042
cx3
 		Ggta1tm1Jbl/Ggta1+
Ightm1Jiac/Ightm1Jiac
Igktm1Jiac/Igktm1Jiac 		involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 MGI:3779044


Genotype
MGI:3779041
cx1
Allelic
Composition		 Ggta1tm1Jbl/Ggta1+
Ightm1Jiac/Ightm1Jiac
Igktm1Jiac/Igk+
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ggta1tm1Jbl mutation (2 available); any Ggta1 mutation (81 available)
Ightm1Jiac mutation (0 available); any Igh mutation (44 available)
Igktm1Jiac mutation (0 available); any Igk mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased mature B cell number ( J:133032 )
• the frequency of B220+ B cells in the periphery is 18.7% compared to 24.7% in mice with just one Igh knock-in allele

hematopoietic system
decreased mature B cell number ( J:133032 )
• the frequency of B220+ B cells in the periphery is 18.7% compared to 24.7% in mice with just one Igh knock-in allele




Genotype
MGI:3779042
cx2
Allelic
Composition		 Ggta1tm1Jbl/Ggta1+
Ightm1Jiac/Igh+
Igktm1Jiac/Igktm1Jiac
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ggta1tm1Jbl mutation (2 available); any Ggta1 mutation (81 available)
Ightm1Jiac mutation (0 available); any Igh mutation (44 available)
Igktm1Jiac mutation (0 available); any Igk mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased mature B cell number ( J:133032 )
• the frequency of B220+ B cells in the periphery is 10.1% compared to 24.7% in mice with just one Igk knock-in allele

hematopoietic system
decreased mature B cell number ( J:133032 )
• the frequency of B220+ B cells in the periphery is 10.1% compared to 24.7% in mice with just one Igk knock-in allele




Genotype
MGI:3779044
cx3
Allelic
Composition		 Ggta1tm1Jbl/Ggta1+
Ightm1Jiac/Ightm1Jiac
Igktm1Jiac/Igktm1Jiac
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ggta1tm1Jbl mutation (2 available); any Ggta1 mutation (81 available)
Ightm1Jiac mutation (0 available); any Igh mutation (44 available)
Igktm1Jiac mutation (0 available); any Igk mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal B cell selection ( J:133032 )
• anti-alphaGal IgM is detectable in the sera of mice
• the frequency of B cells expressing anti-alphaGal IgM in the spleen is higher than controls
decreased mature B cell number ( J:133032 )
• the frequency of B220+ B cells in the periphery is 6.6% compared to 24.7% in mice with just one knock-in allele for Igk and Igh
abnormal B cell physiology ( J:133032 )
• the anti-alphaGal IgM produced by B cells has a lower affinity for antigen than immunoglobulins produced in mice with with no endogenous expression of alphaGal

immune system
abnormal B cell selection ( J:133032 )
• anti-alphaGal IgM is detectable in the sera of mice
• the frequency of B cells expressing anti-alphaGal IgM in the spleen is higher than controls
decreased mature B cell number ( J:133032 )
• the frequency of B220+ B cells in the periphery is 6.6% compared to 24.7% in mice with just one knock-in allele for Igk and Igh
abnormal B cell physiology ( J:133032 )
• the anti-alphaGal IgM produced by B cells has a lower affinity for antigen than immunoglobulins produced in mice with with no endogenous expression of alphaGal




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11/12/2024
MGI 6.24 		The Jackson Laboratory