Phenotypes associated with this allele

• Allele Symbol: Mchr1^tm1.1Blak
• Allele Name: targeted mutation 1.1, Bernard Lakaye
• Allele ID: MGI:3778893
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mchr1^tm1.1Blak/Mchr1^tm1.1Blak	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * FVB/N	MGI:3783583

Genotype
MGI:3783583

hm1

• Allelic Composition: Mchr1^tm1.1Blak/Mchr1^tm1.1Blak
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to xenobiotic ( J:133199 )

• following administration of 120 mg/kg modafinil, mice exhibit a lower wakefulness response intensity than in wild-type mice

• following administration of 120 mg/kg modafinil, sleep wave sleep and paradoxical sleep are less significantly altered that in wild-type mice

• mice recover normal sleeping patterns more quickly than wild-type mice following treatment with modafinil

• high doses of modafinil are less effective in inducing wakefulness than low doses unlike in wild-type mice

abnormal sleep pattern ( J:133199 )

• mice exhibit a longer duration of paradoxical sleep compared to wild-type mice

• mice exhibit decreased wakefulness duration with an increase in sleep wave sleep duration during the first hour and the first 4 hours of the recovery period compared to wild-type mice

• however, mice do not exhibit a change in the amount of time spent sleeping

abnormal frequency of paradoxical sleep ( J:133199 )

• increased frequency