Analysis Tools
mortality/aging
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• reach 90% lethality by about 90 days after tamoxifen treatment
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• mice begin to die 40 days after tamoxifen treatment with 90% lethality by about 90 days after treatment
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cardiovascular system
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• about 6 weeks after tamoxifen treatment major vascular branches of the ear are dilated and reddened and medium-sized blood vessels are scattered in the subendocardial layer
• after tamoxifen treatment, liver sections show an increase in large vessels
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• after tamoxifen treatment the trachea contains more capillaries which are more branched and enlarged
• after tamoxifen treatment capillaries amid cardiac fibers are enlarged as are capillaries in the renal glomeruli
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• dilated vessels and enlarged glomerular capillaries after tamoxifen treatment
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• sinusoids are dilated after tamoxifen treatment
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• after tamoxifen treatment the size and number of blood vessels in the lung is increased
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• after tamoxifen treatment increased numbers of blood vessels are seen in the dermal and subcutaneous layers of the ear, the trachea contains more capillaries which are more branched and enlarged, more medium sized vessels are present in the subendocardial layer of the heart, and more vessels are seen in the liver and brain
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• about 6 weeks after tamoxifen treatment vessels in the ear, trachea, heart, lung, kidney cortex and glomeruli, liver
• in the lung vessel dilation is accompanied by packed erythrocytes
• in the liver central veins are about 4-times larger than in controls
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hematopoietic system
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• significant increase in hematopoietic stem cells in the liver and spleen after tamoxifen treatment
• increase in the number of colonies formed by spleen and liver cells in a methylcellulose colony forming assay after tamoxifen treatment
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polycythemia
(
J:132720
)
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• after tamoxifen treatment
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• dramatic increase after tamoxifen treatment
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• after tamoxifen treatment
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• after tamoxifen treatment
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• increase in the number of erythroid progenitor and myeloid cells after tamoxifen treatment
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liver/biliary system
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• more strongly colored than controls after tamoxifen treatment
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• sinusoids are dilated after tamoxifen treatment
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renal/urinary system
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• dilated vessels and enlarged glomerular capillaries after tamoxifen treatment
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• glomeruli are enlarged and their capillaries are dilated
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homeostasis/metabolism
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• 230-fold increase in serum erythropoietin levels within 2 weeks of tamoxifen treatment
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immune system
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• after tamoxifen treatment
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• increase in the number of erythroid progenitor and myeloid cells after tamoxifen treatment
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respiratory system
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• after tamoxifen treatment the size and number of blood vessels in the lung is increased
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integument
reddish skin
(
J:132720
)
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• erythemia is more apparent than in Egln2tm1Fong Egln3tm1Fong double homozygotes
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growth/size/body
