Analysis Tools
growth/size/body
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• similar in size at birth and at 2 months of age but significantly smaller than littermate controls at weaning
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cardiovascular system
| N |
• unlike human patients with striate palmoplantar keratoderma disorder, no evidence of cardiomyopathy is detected
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integument
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• over 30% of mice lack hair at weaning with the remainder having sparse coats
• extensive regional hair loss is seen when mice are housed with other mice with regrowth when mice are housed alone
• despite the thinner coat, in a tape-stripping test more hairs are removed compared to wild-type controls
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• delay in coat growth that may be the result of maternal grooming
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sparse hair
(
J:133318
)
|
• over 30% of mice lack hair at weaning with the remainder having sparse coats
• coat remains sparse throughout life
|
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• sections of skin from hypotrichotic regions contain empty cysts in telogen follicles
• cleft between the inner and outer root sheath
• depilated hairs have a naked anagen bulb lacking the inner and outer root sheath
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• fewer desmosomes are identified in the interfolicular epidermis and unlike in wild-type mice, this number is further reduced after EGTA treatment
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• marked thickening of the stratum corneum on the palmoplantar surfaces of the paws
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