Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv targeted mutation 1, Sergei B Koralov MGI:3778925 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• under Th17 conditions, T cells transduced with a cre protein (Tat-Cre) exhibit increased differentiation towards
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• under Th17 conditions, T cells transduced with a cre protein (Tat-Cre) exhibit increased differentiation towards
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• mice exhibit normal brown adipose tissue morphology with reduced body weight compared to single Tyk2 homozygotes
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N |
• mice exhibit improved insulin sensitivity compared to single Tyk2 homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• however, treatment with anti-IL17A antibodies improves survival
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• modest increase in IFNG+ T cells (that also express IL17) indicating a slight expansion of Th1 cells
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• in the gut and lungs
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• in the peripheral lymph nodes and lungs
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• by peripheral T cells
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• Th17 cells infiltrate the airways and cause severe neutrophilic lung inflammation with thickening of the airway epithelium, hypertrophy of the smooth muscle surrounding large and midsized airways and pronounced perivascular, increased mucus production and peribronchial/peribronchiolar inflammatory infiltrates
• however, lung phenotype is improved by treatment with anti-IL17A antibodies
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• Th17 cells infiltrate the airways and cause severe neutrophilic lung inflammation with thickening of the airway epithelium, hypertrophy of the smooth muscle surrounding large and midsized airways and pronounced perivascular, increased mucus production and peribronchial/peribronchiolar inflammatory infiltrates
• however, lung phenotype is improved by treatment with anti-IL17A antibodies
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• modest increase in IFNG+ T cells (that also express IL17) indicating a slight expansion of Th1 cells
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• in the gut and lungs
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• in the peripheral lymph nodes and lungs
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice on a normal chow diet weigh 10% less than littermate controls from weaning until 20 weeks of age
• differences are more pronounced when mice are kept on a high fat diet with mice weighing 15-20% less until the age of 20 weeks
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• there is a significant decrease in plasma epinephrine levels in mice fed a normal diet but not in mice fed a high-fat diet
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• there is a significant decrease in plasma norepinephrine levels in mice fed a normal diet but not in mice fed a high-fat diet
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• 9 week old mice consume 15-20% more oxygen during both day and night phases
• 13 week old mice consume more than 30% oxygen during the light phase and more than 40% oxygen during the night phase
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• a 16 hour fasts leads to significantly lower blood glucose levels in mice fed a high fat diet compared to controls
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• mice on a high fat diet have slightly less circulating insulin levels
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• mice on a high fat diet are significantly more glucose tolerant compared to controls
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• mice of either sex on a normal chow diet displayed a 30% reduction in epigonodal fat-pad weight at 20 weeks of age
• mice on a high fat diet displayed a 40-60 % weight reduction in the epigonodal fat pads at 20 weeks of age
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• mice exhibit a slight postpubertal hyperphagia
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• at 9 weeks of age, mice exhibit a dramatic increase in basal locomotor activity with a 40% increase during the light phase and 60% during the dark phase compared to control mice
• mice exhibit the highest locomotor activity at the beginning of the dark cycle where they were more than twice as active as their littermate controls
• there are also greater increases in fasting-induced hyperactivity than in control mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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