Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-cre)1Jmk
• Allele Name: transgene insertion 1, Jeffery D Molkentin
• Allele ID: MGI:3779100
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rpl22^tm1.1Psam/Rpl22^+ Rpl3l^em1Jmol/Rpl3l^em1Jmol Tg(Myh6-cre)1Jmk/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NJ * C57BL/6NTac	MGI:7434988
cn2	Gata4^tm1.1Sad/Gata4^tm1.1Sad Tg(Myh6-cre)1Jmk/0	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3783260
cn3	Kdm4a^tm1Zpl/Kdm4a^tm1Zpl Tg(Myh6-cre)1Jmk/0	involves: 129S6/SvEv * C57BL/6	MGI:5056146
cn4	Acadvl^tm1Zkhu/Acadvl^tm1Zkhu Tg(Myh6-cre)1Jmk/0	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr	MGI:5578180
cn5	Tg(CMV-cat,-ROCK2*)3-1Koba/0 Tg(Myh6-cre)1Jmk/0	involves: C57BL/6 * C57BL/6JJcl * DBA/2	MGI:5910540

Genotype
MGI:7434988

cn1

• Allelic Composition: Rpl22^tm1.1Psam/Rpl22⁺; Rpl3l^em1Jmol/Rpl3l^em1Jmol; Tg(Myh6-cre)1Jmk/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NJ * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:333030 )

N • mice show normal distributions of ribosomes in cardiomyocytes

Genotype
MGI:3783260

cn2

• Allelic Composition: Gata4^tm1.1Sad/Gata4^tm1.1Sad; Tg(Myh6-cre)1Jmk/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

cardiovascular system

abnormal myocardial fiber morphology ( J:121367 )

• 30% of cells having Gata4 expression are larger than Gata4-deficient cells in the heart

dilated heart ( J:121367 )

• heart displays dilation, but this is less prominent than if deletion is produced by Tg(Myh7-cre)1Jmk

decreased cardiac muscle contractility ( J:121367 )

• significant reduction of fractional shortening is observed at 24 weeks

muscle

abnormal myocardial fiber morphology ( J:121367 )

• 30% of cells having Gata4 expression are larger than Gata4-deficient cells in the heart

decreased cardiac muscle contractility ( J:121367 )

• significant reduction of fractional shortening is observed at 24 weeks

respiratory system

pulmonary edema ( J:121367 )

• following transverse aortic constriction (TAC), severe pulmonary edema is observed

homeostasis/metabolism

pulmonary edema ( J:121367 )

• following transverse aortic constriction (TAC), severe pulmonary edema is observed

Genotype
MGI:5056146

cn3

• Allelic Composition: Kdm4a^tm1Zpl/Kdm4a^tm1Zpl; Tg(Myh6-cre)1Jmk/0
• Genetic Background: involves: 129S6/SvEv * C57BL/6

Kdm4a^tm1Zpl/Kdm4a^tm1Zpl Tg(Myh6-cre)1Jmk/0 mice exhibit abnormal heart phenotypes following transverse aortic constriction

cardiovascular system

cardiovascular system phenotype ( J:173908 )

N • mice exhibit normal baseline cardiac phenotype

decreased myocardial fiber size ( J:173908 )

• following transverse aortic constriction

decreased heart weight ( J:173908 )

• following transverse aortic constriction

abnormal heart left ventricle morphology ( J:173908 )

• following transverse aortic constriction, mice exhibit decreased left ventricular internal dimension in systole compared with wild-type mice

increased cardiac muscle contractility ( J:173908 )

• following transverse aortic constriction

decreased response of heart to induced stress ( J:173908 )

• following transverse aortic constriction, mice exhibit a smaller increase in heart weight to body weight and cross-sectional cardiomyocyte areas and improved cardiac function compared with similarly treated wild-type mice

homeostasis/metabolism

decreased response of heart to induced stress ( J:173908 )

• following transverse aortic constriction, mice exhibit a smaller increase in heart weight to body weight and cross-sectional cardiomyocyte areas and improved cardiac function compared with similarly treated wild-type mice

muscle

decreased myocardial fiber size ( J:173908 )

• following transverse aortic constriction

increased cardiac muscle contractility ( J:173908 )

• following transverse aortic constriction

Genotype
MGI:5578180

cn4

• Allelic Composition: Acadvl^tm1Zkhu/Acadvl^tm1Zkhu; Tg(Myh6-cre)1Jmk/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:208711 )

• in mice exposed to combined stresses of cold and fasting at 2 months

cardiovascular system

abnormal heart morphology ( J:208711 )

• abnormal heart histology at 6 months

• decreased heart ATP content at baseline and with high workload in response to dobutamine challenge

abnormal myocardial fiber morphology ( J:208711 )

• frequent vacuolations

• however, cardiomyocytes exhibit normal fat accumulation and mitochondrial ultrastructure and oxidative function

increased heart weight ( J:208711 )

• at 6 months

abnormal heart left ventricle morphology ( J:208711 )

• increased left ventricular end-diastolic and end-systolic dimensions at 6, but not 3, months

dilated heart left ventricle ( J:208711 )

• at 6, but not 3, months

abnormal cardiovascular system physiology ( J:208711 )

• isolated hearts exhibit reduced systolic and diastolic function compared with control hearts

dilated cardiomyopathy ( J:208711 )

• at 6 months

decreased heart left ventricle muscle contractility ( J:208711 )

• decreased left ventricular fractional shortening at 6 months

decreased heart rate ( J:208711 )

• severe in cold-exposed fasted mice

• however, rewarming rescues and recovers heart rate and function

homeostasis/metabolism

abnormal adaptive thermogenesis ( J:208711 )

• cold-exposed fasted mice exhibit lethargy, increased lethality, reduced respiratory exchange ratio, decreased body temperature, decreased circulating glucose and decreased heart rate and function compared with control mice

decreased circulating glucose level ( J:208711 )

• after 60 minutes of cold exposure and fasting

• however, glucose levels are normal prior to cold exposure

decreased core body temperature ( J:208711 )

• after 45 minutes of cold exposure and fasting

• however, body temperature prior to cold exposure is normal

decreased respiratory quotient ( J:208711 )

• in cold-exposed fasted mice

behavior/neurological

lethargy ( J:208711 )

• in 6 month old mice exposed to cold and fasting

muscle

abnormal myocardial fiber morphology ( J:208711 )

• frequent vacuolations

• however, cardiomyocytes exhibit normal fat accumulation and mitochondrial ultrastructure and oxidative function

dilated cardiomyopathy ( J:208711 )

• at 6 months

decreased heart left ventricle muscle contractility ( J:208711 )

• decreased left ventricular fractional shortening at 6 months

growth/size/body

increased heart weight ( J:208711 )

• at 6 months

Genotype
MGI:5910540

cn5

• Allelic Composition: Tg(CMV-cat,-ROCK2*)3-1Koba/0; Tg(Myh6-cre)1Jmk/0
• Genetic Background: involves: C57BL/6 * C57BL/6JJcl * DBA/2

normal phenotype

no abnormal phenotype detected ( J:242116 )

• mice develop normally with normal life spans and cardiac structure and function and 18 week old hearts show no ventricular thinning, right ventricular dilatation or fibrosis