All Phenotypes Chn1<Gt714Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Chn1^Gt714Lex
gene trap 714, Lexicon Genetics
MGI:3783264

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chn1^Gt714Lex/Chn1^Gt714Lex	involves: 129S5/SvEvBrd	MGI:3809830
cx2	Chn1^Gt714Lex/Chn1⁺ Epha4^tm1Pch/Epha4⁺	involves: 129S2/SvPas * 129S5/SvEvBrd	MGI:3809834

Allelic Composition	Chn1^Gt714Lex/Chn1^Gt714Lex
Genetic Background	involves: 129S5/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chn1^Gt714Lex mutation (0 available); any Chn1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor behavior ( J:128698 )

• unilateral stimulation of the motor cortex leads to exclusively bilateral "EMG" and hind limb flexion

abnormal gait ( J:128698 )

• synchronous hind limb movement, rabbit like hopping gait

nervous system

nervous system phenotype ( J:128698 )

N	• normal overall brain architecture • axonal projections of proprioceptive neurons are normal

abnormal motor neuron innervation pattern ( J:128698 )

• motor cortex axons resistant to ephrinA1 induced growth cone collapse

abnormal spinal cord interneuron morphology ( J:128698 )

• increased number of lumbar region interneurons cross the midline

abnormal spinal nerve morphology ( J:128698 )

• extensive bilateral terminations within the gray matter of the corticospinal tract

muscle

abnormal muscle electrophysiology ( J:128698 )

• unilateral stimulation of the motor cortex leads to bilateral electromyography (EMG) and hind limb flexion in mutant mice, while controls exhibit unilateral EMG and hind limb flexion

Allelic Composition	Chn1^Gt714Lex/Chn1⁺ Epha4^tm1Pch/Epha4⁺
Genetic Background	involves: 129S2/SvPas * 129S5/SvEvBrd