Phenotypes associated with this allele

• Allele Symbol: Prex2^{Gt(RRD186)Byg}
• Allele Name: gene trap RRD186, BayGenomics
• Allele ID: MGI:3783295
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prex2^Gt(RRD186)Byg/Prex2^Gt(RRD186)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3783866
cx2	Prex1^tm1Hcew/Prex1^tm1Hcew Prex2^Gt(RRD186)Byg/Prex2^Gt(RRD186)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3783869
cx3	Prex2^Gt(RRD186)Byg/Prex2^Gt(RRD186)Byg Tg(Pcp2-EGFP)2Yuza/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:3783868

Genotype
MGI:3783866

hm1

• Allelic Composition: Prex2^{Gt(RRD186)Byg}/Prex2^{Gt(RRD186)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Purkinje cell dendrite morphology is altered in Prex2^{Gt(RRD186)Byg}/Prex2^{Gt(RRD186)Byg} mice

behavior/neurological

increased startle reflex ( J:133335 )

• in males

limb grasping ( J:133335 )

• tendency towards limb clasping in mice over 12 months of age

impaired coordination ( J:133335 )

• although performance improves with training mice do not perform as efficiently on a rotarod as do wild-type controls

• performance on a rotarod decreases with age and the deficit is more severe in females

• females and males tend to cling to the rod and passively turn more than wild-type mice and this defect is more obvious in females

short stride length ( J:133335 )

• somewhat reduced in old mice

decreased locomotor activity ( J:133335 )

• decrease in basic locomotor activity that is more obvious in males and tends to increase with age in males but not females

growth/size/body

decreased body weight ( J:133335 )

• in older females

nervous system

abnormal Purkinje cell dendrite morphology ( J:133335 )

• the main dendritic trunk appears shriveled and unordered

Genotype
MGI:3783869

cx2

• Allelic Composition: Prex1^tm1Hcew/Prex1^tm1Hcew; Prex2^{Gt(RRD186)Byg}/Prex2^{Gt(RRD186)Byg}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Limb clasping in Prex1^tm1Hcew/Prex1^tm1Hcew Prex2^{Gt(RRD186)Byg}/Prex2^{Gt(RRD186)Byg} mice

nervous system

abnormal Purkinje cell dendrite morphology ( J:133335 )

• both the main dendritic trunk and the entire dendritic tree appear disordered

behavior/neurological

behavior/neurological phenotype ( J:133335 )

N • unlike mice homozygous for Depdc2^{Gt(RRD186)Byg} only acoustic startle response is not significantly different from controls

limb grasping ( J:133335 )

• seen in younger mice compared to Depdc2^{Gt(RRD186)Byg} single homozygotes

impaired coordination ( J:133335 )

• motor learning is normal but performance on the rotarod is impaired in both males and females at an earlier age than in Depdc2^{Gt(RRD186)Byg} single homozygotes

• mice take significantly longer to complete beam walking tests

short stride length ( J:133335 )

• significantly reduced at an earlier age and to a greater extent than in Depdc2^{Gt(RRD186)Byg} single homozygotes

decreased locomotor activity ( J:133335 )

• decrease in basic locomotor activity that is stronger and occurs earlier than in Depdc2^{Gt(RRD186)Byg} single homozygotes

growth/size/body

decreased body weight ( J:133335 )

• in males

increased body weight ( J:133335 )

• in females

Genotype
MGI:3783868

cx3

• Allelic Composition: Prex2^{Gt(RRD186)Byg}/Prex2^{Gt(RRD186)Byg}; Tg(Pcp2-EGFP)2Yuza/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

nervous system

abnormal Purkinje cell dendrite morphology ( J:133335 )

• the main dendritic trunk appears shriveled and unordered

• the diameter of the main dendrite is reduced by about 20% and the length of the main dendrite tends to be shorter